Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion

Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and...

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Autores principales: Abu Zeid, Isam M., Al-Asmari, Khalid M., Altayb, Hisham N., Al-Attar, Atef M., Qahl, Safa H., Alomar, Mohammed Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948629/
https://www.ncbi.nlm.nih.gov/pubmed/35330101
http://dx.doi.org/10.3390/life12030350
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author Abu Zeid, Isam M.
Al-Asmari, Khalid M.
Altayb, Hisham N.
Al-Attar, Atef M.
Qahl, Safa H.
Alomar, Mohammed Y.
author_facet Abu Zeid, Isam M.
Al-Asmari, Khalid M.
Altayb, Hisham N.
Al-Attar, Atef M.
Qahl, Safa H.
Alomar, Mohammed Y.
author_sort Abu Zeid, Isam M.
collection PubMed
description Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and olive oils (400 mg/kg) for 7 weeks. Exposure to MAL resulted in statistically altered antioxidant enzymes and histopathological findings of necrotic seminiferous tubules and spermatogenetic arrest in rats after seven weeks of treatment. The effects of MAL intoxication on physiological and histopathological changes were improved by the use of these oils. Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Coffee oil and olive oil were found to be promising therapeutic agents for MAL-induced testicular toxicity and oxidative damage.
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spelling pubmed-89486292022-03-26 Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion Abu Zeid, Isam M. Al-Asmari, Khalid M. Altayb, Hisham N. Al-Attar, Atef M. Qahl, Safa H. Alomar, Mohammed Y. Life (Basel) Article Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and olive oils (400 mg/kg) for 7 weeks. Exposure to MAL resulted in statistically altered antioxidant enzymes and histopathological findings of necrotic seminiferous tubules and spermatogenetic arrest in rats after seven weeks of treatment. The effects of MAL intoxication on physiological and histopathological changes were improved by the use of these oils. Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Coffee oil and olive oil were found to be promising therapeutic agents for MAL-induced testicular toxicity and oxidative damage. MDPI 2022-02-28 /pmc/articles/PMC8948629/ /pubmed/35330101 http://dx.doi.org/10.3390/life12030350 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abu Zeid, Isam M.
Al-Asmari, Khalid M.
Altayb, Hisham N.
Al-Attar, Atef M.
Qahl, Safa H.
Alomar, Mohammed Y.
Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion
title Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion
title_full Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion
title_fullStr Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion
title_full_unstemmed Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion
title_short Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion
title_sort predominance of antioxidants in some edible plant oils in ameliorating oxidative stress and testicular toxicity induced by malathion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948629/
https://www.ncbi.nlm.nih.gov/pubmed/35330101
http://dx.doi.org/10.3390/life12030350
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