Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing

We develop a population pharmacokinetic model to describe Busulfan pharmacokinetics in paediatric patients and investigate by simulations the impact of various sampling schedules on the calculation of AUC. Seventy-six children had 2 h infusions every 6 h. A two-compartment linear model was found to...

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Detalles Bibliográficos
Autores principales: Neroutsos, Efthymios, Nalda-Molina, Ricardo, Paisiou, Anna, Zisaki, Kalliopi, Goussetis, Evgenios, Spyridonidis, Alexandros, Kitra, Vasiliki, Grafakos, Stelios, Valsami, Georgia, Dokoumetzidis, Aristides
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948694/
https://www.ncbi.nlm.nih.gov/pubmed/35336021
http://dx.doi.org/10.3390/pharmaceutics14030647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948694/
https://www.ncbi.nlm.nih.gov/pubmed/35336021
http://dx.doi.org/10.3390/pharmaceutics14030647

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