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Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies

Herpes simplex virus-1 (HSV-1) is highly contagious, and there is a need for a therapeutic means to eradicate it. We have identified an siRNA (siHSV) that knocks down gene expression of the infected cell protein 0 (ICP0), which is important in the regulation of HSV infection. The selected siHSV was...

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Detalles Bibliográficos
Autores principales:	Jbara-Agbaria, Doaa, Blondzik, Saskia, Burger-Kentischer, Anke, Agbaria, Majd, Nordling-David, Mirjam M., Giterman, Anna, Aizik, Gil, Rupp, Steffen, Golomb, Gershon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948811/ https://www.ncbi.nlm.nih.gov/pubmed/35336008 http://dx.doi.org/10.3390/pharmaceutics14030633

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