Cargando…

Reducing the Excess Activin Signaling Rescues Muscle Degeneration in Myotonic Dystrophy Type 2 Drosophila Model

Expanded non-coding RNA repeats of CCUG are the underlying genetic causes for myotonic dystrophy type 2 (DM2). There is an urgent need for effective medications and potential drug targets that may alleviate the progression of the disease. In this study, 3140 small-molecule drugs from FDA-approved li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Jing, Guan, Xin-Xin, Zhu, Ying-Bao, Deng, Hai-Tao, Li, Guang-Xu, Guo, Yi-Chen, Jin, Peng, Duan, Ran-Hui, Huang, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948895/ https://www.ncbi.nlm.nih.gov/pubmed/35330385 http://dx.doi.org/10.3390/jpm12030385

Ejemplares similares

Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction
por: Chakraborty, Mouli, et al.
Publicado: (2015)

Modeling of Myotonic Dystrophy Cardiac Phenotypes in Drosophila
por: Chakraborty, Mouli, et al.
Publicado: (2018)

Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
por: Llamusi, Beatriz, et al.
Publicado: (2013)

Myotonic dystrophy
por: Patterson, VH
Publicado: (1990)

Resistance Exercise Training Rescues Mitochondrial Dysfunction in Skeletal Muscle of Patients with Myotonic Dystrophy Type 1
por: Di Leo, Valeria, et al.
Publicado: (2023)

Defined d-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease
por: Rapisarda, Anna, et al.
Publicado: (2021)

Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy
por: Chakraborty, Mouli, et al.
Publicado: (2018)

Modeling Myotonic Dystrophy Type 2 Using Drosophila melanogaster
por: Marzullo, Marta, et al.
Publicado: (2023)

Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model
por: deLorimier, Elaine, et al.
Publicado: (2014)

Cancer and Myotonic Dystrophy
por: D’Ambrosio, Eleonora S., et al.
Publicado: (2023)

Affection of the Gastrointestinal Smooth Muscles in Myotonic Dystrophy Is Not Unusual
por: Finsterer, Josef, et al.
Publicado: (2019)

Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model
por: Bargiela, Ariadna, et al.
Publicado: (2015)

TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2
por: Bosè, Francesca, et al.
Publicado: (2019)

Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model
por: Shen, Xiaopeng, et al.
Publicado: (2021)

Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy
por: Mootha, V. Vinod, et al.
Publicado: (2017)

Overexpression of CUGBP1 in Skeletal Muscle from Adult Classic Myotonic Dystrophy Type 1 but Not from Myotonic Dystrophy Type 2
por: Cardani, Rosanna, et al.
Publicado: (2013)

I-18 Chronic muscle electrical stimulation in Myotonic Dystrophy
por: Chisari, C.
Publicado: (2011)

Muscle wasting in myotonic dystrophies: a model of premature aging
por: Mateos-Aierdi, Alba Judith, et al.
Publicado: (2015)

Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy
por: André, Laurène M., et al.
Publicado: (2018)

Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy
por: Evangelista, Morgana de Araújo, et al.
Publicado: (2017)

Desflurane anaesthesia in myotonic dystrophy
por: Gandhi, Ranju, et al.
Publicado: (2011)

Myotonic Dystrophy: An Anaesthetic Dilemma
por: Gupta, N, et al.
Publicado: (2009)

Cardiac involvement in myotonic dystrophy
por: Khalighi, Koroush, et al.
Publicado: (2015)

Steakhouse Syndrome in Myotonic Dystrophy
por: Ogasawara, Nobuhiko, et al.
Publicado: (2017)

Cutaneous findings in myotonic dystrophy
por: Kong, Ha Eun, et al.
Publicado: (2022)

Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression
por: Sabater-Arcis, Maria, et al.
Publicado: (2021)

Repression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophy
por: Berger, Dara S., et al.
Publicado: (2012)

A Case of Myotonic Dystrophy with Electrolyte Imbalance
por: Ko, Weon-Jin, et al.
Publicado: (2013)

Marathoning with myotonic dystrophy type 2 (proximal myotonic myopathy) and leukopenia
por: Finsterer, Josef, et al.
Publicado: (2017)

Muscle Chloride Channel Dysfunction in Two Mouse Models of Myotonic Dystrophy
por: Lueck, John D., et al.
Publicado: (2007)

Dissecting Pathogenetic Mechanisms and Therapeutic Strategies in Drosophila Models of Myotonic Dystrophy Type 1
por: Souidi, Anissa, et al.
Publicado: (2018)

Respiratory failure in myotonic dystrophy 1
Publicado: (2013)

Multidimensional aspects of pain in myotonic dystrophies
por: Peric, Marina, et al.
Publicado: (2015)

Myotonic Dystrophy—A Progeroid Disease?
por: Meinke, Peter, et al.
Publicado: (2018)

Hyperostosis Frontalis Interna in Myotonic Dystrophy
por: Suzuki, Keisuke, et al.
Publicado: (2017)

Core Clinical Phenotypes in Myotonic Dystrophies
por: Wenninger, Stephan, et al.
Publicado: (2018)

Achalasia in a Patient with Myotonic Dystrophy
por: Sato, Hiroki, et al.
Publicado: (2019)

Epigenetics of Myotonic Dystrophies: A Minireview
por: Visconti, Virginia Veronica, et al.
Publicado: (2021)

Myotonic Dystrophies: A Genetic Overview
por: Soltanzadeh, Payam
Publicado: (2022)

Disrupting the Molecular Pathway in Myotonic Dystrophy
por: Xing, Xiaomeng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6dtuv3868l8khg2bf815igjlio