Cargando…

Strategies for Targeted Delivery of Exosomes to the Brain: Advantages and Challenges

Delivering therapeutics to the central nervous system (CNS) is difficult because of the blood–brain barrier (BBB). Therapeutic delivery across the tight junctions of the BBB can be achieved through various endogenous transportation mechanisms. Receptor-mediated transcytosis (RMT) is one of the most...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Hojun, Choi, Kyungsun, Kim, Dae-Hwan, Oh, Byung-Koo, Yim, Hwayoung, Jo, Soojin, Choi, Chulhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948948/ https://www.ncbi.nlm.nih.gov/pubmed/35336049 http://dx.doi.org/10.3390/pharmaceutics14030672

Ejemplares similares

Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes
por: Choi, Hojun, et al.
Publicado: (2021)

Targeted Delivery of Exosomes Armed with Anti-Cancer Therapeutics
por: Choi, Hojun, et al.
Publicado: (2022)

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
por: Yim, Nambin, et al.
Publicado: (2016)

Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with (89)Zr Radioisotope in Mice and Rats
por: Choi, Hojun, et al.
Publicado: (2022)

Downregulation of OPA3 Is Responsible for Transforming Growth Factor-β-Induced Mitochondrial Elongation and F-Actin Rearrangement in Retinal Pigment Epithelial ARPE-19 Cells
por: Ryu, Seung-Wook, et al.
Publicado: (2013)

Manufacturing Therapeutic Exosomes: from Bench to Industry
por: Ahn, So-Hee, et al.
Publicado: (2022)

Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality
por: Choi, Hojun, et al.
Publicado: (2020)

Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models
por: Sheller-Miller, Samantha, et al.
Publicado: (2021)

Mutant Ubiquitin UBB+1 Induces Mitochondrial Fusion by Destabilizing Mitochondrial Fission-Specific Proteins and Confers Resistance to Oxidative Stress-Induced Cell Death in Astrocytic Cells
por: Yim, Nambin, et al.
Publicado: (2014)

Mesenchymal Stem Cell‐Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform
por: Baek, Gyuhyeon, et al.
Publicado: (2019)

Constitutive Expression of MAP Kinase Phosphatase-1 Confers Multi-drug Resistance in Human Glioblastoma Cells
por: Yu, Hana, et al.
Publicado: (2012)

Therapeutic exosomes for various human diseases: Special issue of BMB Reports in 2022
por: Choi, Chulhee
Publicado: (2022)

Mutant Ubiquitin Attenuates Interleukin-1β- and Tumor Necrosis Factor-α-Induced Pro-Inflammatory Signaling in Human Astrocytic Cells
por: Choi, Kyungsun, et al.
Publicado: (2013)

Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19
por: Choi, Kyungsun, et al.
Publicado: (2012)

Extracellular vesicles as novel carriers for therapeutic molecules
por: Yim, Nambin, et al.
Publicado: (2016)

Differential dependency of human glioblastoma cells on vascular endothelial growth factor-A signaling via neuropilin-1
por: Lee, Jungwhoi, et al.
Publicado: (2022)

Phenotypic Modulation of Primary Vascular Smooth Muscle Cells by Short-Term Culture on Micropatterned Substrate
por: Chang, Soyoung, et al.
Publicado: (2014)

Atypical induction of HIF-1α expression by pericellular Notch1 signaling suffices for the malignancy of glioblastoma multiforme cells
por: Lee, Jungwhoi, et al.
Publicado: (2022)

Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice
por: Kim, Hee-Hoon, et al.
Publicado: (2023)

Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis
por: Mirzaaghasi, Amin, et al.
Publicado: (2021)

Transcriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: Implications for tumor invasion and migration
por: Lim, Seul Ye, et al.
Publicado: (2014)

Multiplex Analysis of Cytokines in the Serum and Cerebrospinal Fluid of Patients With Alzheimer's Disease by Color-Coded Bead Technology
por: Choi, Chulhee, et al.
Publicado: (2008)

Efficacy of Bee Venom Acupuncture for Chronic Low Back Pain: A Randomized, Double-Blinded, Sham-Controlled Trial
por: Seo, Byung-Kwan, et al.
Publicado: (2017)

Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response
por: Kang, Dong Hoon, et al.
Publicado: (2015)

The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next
por: Song, Yonghee, et al.
Publicado: (2020)

Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy
por: Kim, Hyosuk, et al.
Publicado: (2021)

Local Drug Delivery Strategies for Glioblastoma Treatment
por: Cha, Gi Doo, et al.
Publicado: (2022)

The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells
por: Ahn, Jungryul, et al.
Publicado: (2017)

Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging
por: Han, Hwa Seung, et al.
Publicado: (2021)

Ephedra-Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat Diet-Induced Obesity in Rats
por: Wang, Jing-Hua, et al.
Publicado: (2017)

Exosomes as nanocarriers for siRNA delivery: paradigms and challenges
por: Shahabipour, Fahimeh, et al.
Publicado: (2016)

Exosome-Based Carrier for RNA Delivery: Progress and Challenges
por: Lu, Yicheng, et al.
Publicado: (2023)

Overcome the barriers of the skin: exosome therapy
por: Yang, Gi Hoon, et al.
Publicado: (2021)

In vivo therapeutic effect of combination treatment with metformin and Scutellaria baicalensis on maintaining bile acid homeostasis
por: Han, Kyungsun, et al.
Publicado: (2017)

Oral Cell-Targeted Delivery Systems Constructed of Edible Materials: Advantages and Challenges
por: Li, Xiaolong, et al.
Publicado: (2022)

Gamified Neurorehabilitation Strategies for Post-stroke Motor Recovery: Challenges and Advantages
por: Tosto-Mancuso, Jenna, et al.
Publicado: (2022)

Vascular organoids: unveiling advantages, applications, challenges, and disease modelling strategies
por: Naderi-Meshkin, Hojjat, et al.
Publicado: (2023)

Current Strategies for Exosome Cargo Loading and Targeting Delivery
por: Zeng, Haifeng, et al.
Publicado: (2023)

Noninvasive Optical Measurement of Cerebral Blood Flow in Mice Using Molecular Dynamics Analysis of Indocyanine Green
por: Ku, Taeyun, et al.
Publicado: (2012)

Learning Curve Associated with Complications in Biportal Endoscopic Spinal Surgery: Challenges and Strategies
por: Choi, Dae-Jung, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0hgk7gasf73qpbm06ksj6insbb