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Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis

Three genetically determined enzyme defects of purine de novo synthesis (PDNS) have been identified so far in humans: adenylosuccinate lyase (ADSL) deficiency, 5-amino-4-imidazole carboxamide-ribosiduria (AICA-ribosiduria), and deficiency in bifunctional enzyme phosphoribosylaminoimidazole carboxyla...

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Detalles Bibliográficos
Autores principales:	Mádrová, Lucie, Součková, Olga, Brumarová, Radana, Dobešová, Dana, Václavík, Jan, Kouřil, Štěpán, de Sousa, Julie, Friedecká, Jaroslava, Friedecký, David, Barešová, Veronika, Zikánová, Marie, Adam, Tomáš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948957/ https://www.ncbi.nlm.nih.gov/pubmed/35323684 http://dx.doi.org/10.3390/metabo12030241

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