Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202

Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of th...

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Detalles Bibliográficos
Autores principales: Shao, Surun, Wang, Xueni, She, Jianglian, Zhang, Han, Pang, Xiaoyan, Lin, Xiuping, Zhou, Xuefeng, Liu, Yonghong, Li, Yunqiu, Yang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948984/
https://www.ncbi.nlm.nih.gov/pubmed/35335187
http://dx.doi.org/10.3390/molecules27061823
Descripción
Sumario:Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC(50) value of 1.31 μM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC(50) value of 2.32 μM.

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