Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202

Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of th...

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Autores principales: Shao, Surun, Wang, Xueni, She, Jianglian, Zhang, Han, Pang, Xiaoyan, Lin, Xiuping, Zhou, Xuefeng, Liu, Yonghong, Li, Yunqiu, Yang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948984/
https://www.ncbi.nlm.nih.gov/pubmed/35335187
http://dx.doi.org/10.3390/molecules27061823
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author Shao, Surun
Wang, Xueni
She, Jianglian
Zhang, Han
Pang, Xiaoyan
Lin, Xiuping
Zhou, Xuefeng
Liu, Yonghong
Li, Yunqiu
Yang, Bin
author_facet Shao, Surun
Wang, Xueni
She, Jianglian
Zhang, Han
Pang, Xiaoyan
Lin, Xiuping
Zhou, Xuefeng
Liu, Yonghong
Li, Yunqiu
Yang, Bin
author_sort Shao, Surun
collection PubMed
description Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC(50) value of 1.31 μM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC(50) value of 2.32 μM.
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spelling pubmed-89489842022-03-26 Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202 Shao, Surun Wang, Xueni She, Jianglian Zhang, Han Pang, Xiaoyan Lin, Xiuping Zhou, Xuefeng Liu, Yonghong Li, Yunqiu Yang, Bin Molecules Article Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC(50) value of 1.31 μM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC(50) value of 2.32 μM. MDPI 2022-03-11 /pmc/articles/PMC8948984/ /pubmed/35335187 http://dx.doi.org/10.3390/molecules27061823 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shao, Surun
Wang, Xueni
She, Jianglian
Zhang, Han
Pang, Xiaoyan
Lin, Xiuping
Zhou, Xuefeng
Liu, Yonghong
Li, Yunqiu
Yang, Bin
Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
title Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
title_full Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
title_fullStr Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
title_full_unstemmed Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
title_short Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
title_sort diversified chaetoglobosins from the marine-derived fungus emericellopsis sp. scsio41202
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948984/
https://www.ncbi.nlm.nih.gov/pubmed/35335187
http://dx.doi.org/10.3390/molecules27061823
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