Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage

GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that Gcn1 mutant mice lacking the GCN2-binding domain suffer from growth retardation and postnatal lethality via GCN2-ind...

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Detalles Bibliográficos
Autores principales: Liu, Jun, Kasai, Shuya, Tatara, Yota, Yamazaki, Hiromi, Mimura, Junsei, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Sato, Tsubasa, Ozaki, Taku, Tanji, Kunikazu, Wakabayashi, Koichi, Maeda, Hayato, Mizukami, Hiroki, Shinkai, Yasuhiro, Kumagai, Yoshito, Tomita, Hirofumi, Itoh, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949040/
https://www.ncbi.nlm.nih.gov/pubmed/35328622
http://dx.doi.org/10.3390/ijms23063201

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