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Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients
Clinical signs and symptoms of COVID-19 varied from asymptomatic forms to severe, life-threatening conditions that required treatment in intensive care units. These severe forms of illness are connected with a hypercoagulable state due to excessive inflammation, hypoxia, immobilisation, and altered...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949095/ https://www.ncbi.nlm.nih.gov/pubmed/35329864 http://dx.doi.org/10.3390/jcm11061538 |
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author | Glavinic, Robert Marcic, Ljiljana Dumancic, Stipe Pavicic Ivelja, Mirela Jeličić, Irena Kalibovic Govorko, Danijela Medvedec Mikić, Ivana |
author_facet | Glavinic, Robert Marcic, Ljiljana Dumancic, Stipe Pavicic Ivelja, Mirela Jeličić, Irena Kalibovic Govorko, Danijela Medvedec Mikić, Ivana |
author_sort | Glavinic, Robert |
collection | PubMed |
description | Clinical signs and symptoms of COVID-19 varied from asymptomatic forms to severe, life-threatening conditions that required treatment in intensive care units. These severe forms of illness are connected with a hypercoagulable state due to excessive inflammation, hypoxia, immobilisation, and altered angiotensin-converting enzyme 2 (ACE-2). In total, 17 COVID-19 positive patients were diagnosed with peripheral arterial thrombosis (AT), 13 of them had COVID-19 pneumonia. Laboratory findings in patients with X-ray confirmed pneumonia showed a four times higher neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP) and three times higher lactate dehydrogenase level (LDH) than patients without confirmed pneumonia. Patients with pneumonia had significantly more bilateral occlusions of the lower extremities and a significantly higher percentage with complete occlusion of the arteries than patients without pneumonia. The rate of limb loss was 35.3%. They were all from the group with COVID-19 pneumonia. Ten out of thirteen patients with pneumonia died due to acute respiratory distress syndrome (ARDS). All patients without pneumonia were discharged from the hospital. The aim of this retrospective study was to report the incidence of arterial thrombosis of lower extremities and their complications in the acute phase of the infection among COVID-19 patients admitted to the hospital for treatment. |
format | Online Article Text |
id | pubmed-8949095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89490952022-03-26 Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients Glavinic, Robert Marcic, Ljiljana Dumancic, Stipe Pavicic Ivelja, Mirela Jeličić, Irena Kalibovic Govorko, Danijela Medvedec Mikić, Ivana J Clin Med Article Clinical signs and symptoms of COVID-19 varied from asymptomatic forms to severe, life-threatening conditions that required treatment in intensive care units. These severe forms of illness are connected with a hypercoagulable state due to excessive inflammation, hypoxia, immobilisation, and altered angiotensin-converting enzyme 2 (ACE-2). In total, 17 COVID-19 positive patients were diagnosed with peripheral arterial thrombosis (AT), 13 of them had COVID-19 pneumonia. Laboratory findings in patients with X-ray confirmed pneumonia showed a four times higher neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP) and three times higher lactate dehydrogenase level (LDH) than patients without confirmed pneumonia. Patients with pneumonia had significantly more bilateral occlusions of the lower extremities and a significantly higher percentage with complete occlusion of the arteries than patients without pneumonia. The rate of limb loss was 35.3%. They were all from the group with COVID-19 pneumonia. Ten out of thirteen patients with pneumonia died due to acute respiratory distress syndrome (ARDS). All patients without pneumonia were discharged from the hospital. The aim of this retrospective study was to report the incidence of arterial thrombosis of lower extremities and their complications in the acute phase of the infection among COVID-19 patients admitted to the hospital for treatment. MDPI 2022-03-11 /pmc/articles/PMC8949095/ /pubmed/35329864 http://dx.doi.org/10.3390/jcm11061538 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Glavinic, Robert Marcic, Ljiljana Dumancic, Stipe Pavicic Ivelja, Mirela Jeličić, Irena Kalibovic Govorko, Danijela Medvedec Mikić, Ivana Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients |
title | Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients |
title_full | Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients |
title_fullStr | Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients |
title_full_unstemmed | Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients |
title_short | Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients |
title_sort | acute arterial thrombosis of lower extremities in covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949095/ https://www.ncbi.nlm.nih.gov/pubmed/35329864 http://dx.doi.org/10.3390/jcm11061538 |
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