Cargando…

Identification of Genetic Risk Factors of Severe COVID-19 Using Extensive Phenotypic Data: A Proof-of-Concept Study in a Cohort of Russian Patients

The COVID-19 pandemic has drawn the attention of many researchers to the interaction between pathogen and host genomes. Over the last two years, numerous studies have been conducted to identify the genetic risk factors that predict COVID-19 severity and outcome. However, such an analysis might be co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shcherbak, Sergey G., Changalidi, Anton I., Barbitoff, Yury A., Anisenkova, Anna Yu., Mosenko, Sergei V., Asaulenko, Zakhar P., Tsay, Victoria V., Polev, Dmitrii E., Kalinin, Roman S., Eismont, Yuri A., Glotov, Andrey S., Garbuzov, Evgeny Y., Chernov, Alexander N., Klitsenko, Olga A., Ushakov, Mikhail O., Shikov, Anton E., Urazov, Stanislav P., Baranov, Vladislav S., Glotov, Oleg S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949130/ https://www.ncbi.nlm.nih.gov/pubmed/35328087 http://dx.doi.org/10.3390/genes13030534

Ejemplares similares

Basic Predictive Risk Factors for Cytokine Storms in COVID-19 Patients
por: Shcherbak, Sergey G., et al.
Publicado: (2021)

Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome
por: Shikov, Anton E., et al.
Publicado: (2020)

Molecular Genetics and Pathogenesis of the Floating Harbor Syndrome: Case Report of Long-Term Growth Hormone Treatment and a Literature Review
por: Turkunova, Mariia E., et al.
Publicado: (2022)

Whole‐exome sequencing provides insights into monogenic disease prevalence in Northwest Russia
por: Barbitoff, Yury A., et al.
Publicado: (2019)

Systematic dissection of biases in whole-exome and whole-genome sequencing reveals major determinants of coding sequence coverage
por: Barbitoff, Yury A., et al.
Publicado: (2020)

RNA Sequencing of Whole Blood Defines the Signature of High Intensity Exercise at Altitude in Elite Speed Skaters
por: Glotov, Andrey S., et al.
Publicado: (2022)

Overview of Transcriptomic Research on Type 2 Diabetes: Challenges and Perspectives
por: Tonyan, Ziravard N., et al.
Publicado: (2022)

Identification of Novel Candidate Markers of Type 2 Diabetes and Obesity in Russia by Exome Sequencing with a Limited Sample Size
por: Barbitoff, Yury A., et al.
Publicado: (2018)

Identification of novel variants in the LDLR gene in Russian patients with familial hypercholesterolemia using targeted sequencing
por: Miroshnikova, Valentina V., et al.
Publicado: (2021)

Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection
por: Glotov, O. S., et al.
Publicado: (2021)

Human Exome Sequencing and Prospects for Predictive Medicine: Analysis of International Data and Own Experience
por: Glotov, Oleg S., et al.
Publicado: (2023)

Clinical and Genetic Characteristics of Pediatric Patients with Hypophosphatasia in the Russian Population
por: Glotov, Oleg S., et al.
Publicado: (2022)

Whole-exome sequencing in Russian children with non-type 1 diabetes mellitus reveals a wide spectrum of genetic variants in MODY-related and unrelated genes
por: Glotov, Oleg S., et al.
Publicado: (2019)

Evaluation of Gut Microbiota in Healthy Persons and Type 1 Diabetes Mellitus Patients in North-Western Russia
por: Chukhlovin, Alexei B., et al.
Publicado: (2023)

Systematic benchmark of state-of-the-art variant calling pipelines identifies major factors affecting accuracy of coding sequence variant discovery
por: Barbitoff, Yury A., et al.
Publicado: (2022)

The Telomeric Repeats of HHV-6A Do Not Determine the Chromosome into Which the Virus Is Integrated
por: Kusakin, Aleksey V., et al.
Publicado: (2023)

Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications
por: Changalidis, Anton I., et al.
Publicado: (2022)

Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes
por: Nasykhova, Yulia A, et al.
Publicado: (2019)

Biobanking as a Tool for Genomic Research: From Allele Frequencies to Cross-Ancestry Association Studies
por: Lazareva, Tatyana E., et al.
Publicado: (2022)

Current Status and Prospects of the Single-Cell Sequencing Technologies for Revealing the Pathogenesis of Pregnancy-Associated Disorders
por: Naydenov, Dmitry D., et al.
Publicado: (2023)

Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits
por: Shikov, Anton E., et al.
Publicado: (2020)

Reproductive History of a Woman With 8p and 18p Genetic Imbalance and Minor Phenotypic Abnormalities
por: Pendina, Anna A., et al.
Publicado: (2019)

Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes
por: Baranova, Tatyana, et al.
Publicado: (2022)

Virulent Properties of Russian Bovine Viral Diarrhea Virus Strains in Experimentally Infected Calves
por: Glotov, Alexander G., et al.
Publicado: (2016)

Statistical Dissection of the Genetic Determinants of Phenotypic Heterogeneity in Genes with Multiple Associated Rare Diseases
por: Lazareva, Tatyana E., et al.
Publicado: (2023)

A Data-Driven Review of the Genetic Factors of Pregnancy Complications
por: Barbitoff, Yury A., et al.
Publicado: (2020)

Description of the First Registered Case of Lopes–Maciel–Rodan Syndrome in Russia
por: Koshevaya, Yuliya S., et al.
Publicado: (2022)

Development of 2′-O-Methyl and LNA Antisense Oligonucleotides for SMN2 Splicing Correction in SMA Cells
por: Maretina, Marianna, et al.
Publicado: (2023)

Development of SNP Set for the Marker-Assisted Selection of Guar (Cyamopsis tetragonoloba (L.) Taub.) Based on a Custom Reference Genome Assembly
por: Grigoreva, Elizaveta, et al.
Publicado: (2021)

Developing and Testing a Real-Time Polymerase Chain Reaction to Identify and Quantify Bovine Respiratory Syncytial Viruses
por: Nefedchenko, A. V., et al.
Publicado: (2021)

Secretory Phospholipase A2 and Interleukin-6 Levels as Predictive Markers of the Severity and Outcome of Patients with COVID-19 Infections
por: Urazov, Stanislav, et al.
Publicado: (2023)

Alkali Earth Catalysts Based on Mesoporous MCM-41 and Al-SBA-15 for Sulfone Removal from Middle Distillates
por: Karakhanov, Eduard, et al.
Publicado: (2019)

Chromosome-level genome assembly and structural variant analysis of two laboratory yeast strains from the Peterhof Genetic Collection lineage
por: Barbitoff, Yury A, et al.
Publicado: (2021)

The role of stress in implementation of Chronic Fatigue Syndrome. Integrative approach to correction of postural, cognitive disorders and cerebral metabolism
por: Safonicheva, Olga, et al.
Publicado: (2014)

Fourteen papers translated from the Russian
por: Aizenshtat, A Ya, et al.
Publicado: (1987)

Placental microRNA expression in pregnancies complicated by superimposed pre-eclampsia on chronic hypertension
por: VASHUKOVA, ELENA S., et al.
Publicado: (2016)

First record of Trichophyton benhamiae isolated from domestic cats in Russia
por: Smagulova, А.М., et al.
Publicado: (2023)

Genetic and Phenotypic Factors Affecting Glycemic Response to Metformin Therapy in Patients with Type 2 Diabetes Mellitus
por: Nasykhova, Yulia A., et al.
Publicado: (2022)

Temporal Control of Seed Development in Dicots: Molecular Bases, Ecological Impact and Possible Evolutionary Ramifications
por: Malovichko, Yury V., et al.
Publicado: (2021)

Current Methods for Recombination Detection in Bacteria
por: Shikov, Anton E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_51nvutaredic8us46kkgm2tjbi