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Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi

Serpula wood-decay fungi occupy a diverse range of natural and man-made ecological niches. Serpula himantioides is a forest-floor generalist with global coverage and strong antagonistic ability, while closely related species Serpula lacrymans contains specialist sister strains with widely differing...

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Autores principales: Cowan, Andrew, Skrede, Inger, Moody, Suzy Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949155/
https://www.ncbi.nlm.nih.gov/pubmed/35330285
http://dx.doi.org/10.3390/jof8030283
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author Cowan, Andrew
Skrede, Inger
Moody, Suzy Clare
author_facet Cowan, Andrew
Skrede, Inger
Moody, Suzy Clare
author_sort Cowan, Andrew
collection PubMed
description Serpula wood-decay fungi occupy a diverse range of natural and man-made ecological niches. Serpula himantioides is a forest-floor generalist with global coverage and strong antagonistic ability, while closely related species Serpula lacrymans contains specialist sister strains with widely differing ecologies. Serpula lacrymans var. shastensis is a forest-floor specialist in terms of resource preference and geographic coverage, while Serpula lacrymans var. lacrymans has successfully invaded the built environment and occupies a building-timber niche. To increase understanding of the cellular machinery required for niche adaptation, a detailed study of the P450 complement of these three strains was undertaken. Cytochrome P450 monooxygenases are present in all fungi and typically seen in high numbers in wood decay species, with putative roles in breakdown of plant extractives and lignocellulose metabolism. Investigating the genomes of these related yet ecologically diverse fungi revealed a high level of concordance in P450 complement, but with key differences in P450 family representation and expression during growth on wood, suggesting P450 proteins may play a role in niche adaptation. Gene expansion of certain key P450 families was noted, further supporting an important role for these proteins during wood decay. The generalist species S. himantioides was found to have the most P450 genes with the greatest family diversity and the highest number of P450 protein families expressed during wood decay.
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spelling pubmed-89491552022-03-26 Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi Cowan, Andrew Skrede, Inger Moody, Suzy Clare J Fungi (Basel) Article Serpula wood-decay fungi occupy a diverse range of natural and man-made ecological niches. Serpula himantioides is a forest-floor generalist with global coverage and strong antagonistic ability, while closely related species Serpula lacrymans contains specialist sister strains with widely differing ecologies. Serpula lacrymans var. shastensis is a forest-floor specialist in terms of resource preference and geographic coverage, while Serpula lacrymans var. lacrymans has successfully invaded the built environment and occupies a building-timber niche. To increase understanding of the cellular machinery required for niche adaptation, a detailed study of the P450 complement of these three strains was undertaken. Cytochrome P450 monooxygenases are present in all fungi and typically seen in high numbers in wood decay species, with putative roles in breakdown of plant extractives and lignocellulose metabolism. Investigating the genomes of these related yet ecologically diverse fungi revealed a high level of concordance in P450 complement, but with key differences in P450 family representation and expression during growth on wood, suggesting P450 proteins may play a role in niche adaptation. Gene expansion of certain key P450 families was noted, further supporting an important role for these proteins during wood decay. The generalist species S. himantioides was found to have the most P450 genes with the greatest family diversity and the highest number of P450 protein families expressed during wood decay. MDPI 2022-03-10 /pmc/articles/PMC8949155/ /pubmed/35330285 http://dx.doi.org/10.3390/jof8030283 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cowan, Andrew
Skrede, Inger
Moody, Suzy Clare
Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi
title Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi
title_full Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi
title_fullStr Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi
title_full_unstemmed Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi
title_short Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi
title_sort cytochrome p450 complement may contribute to niche adaptation in serpula wood-decay fungi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949155/
https://www.ncbi.nlm.nih.gov/pubmed/35330285
http://dx.doi.org/10.3390/jof8030283
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