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Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France
In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949168/ https://www.ncbi.nlm.nih.gov/pubmed/35335681 http://dx.doi.org/10.3390/pathogens11030356 |
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author | Farfour, Eric Dortet, Laurent Guillard, Thomas Chatelain, Nicolas Poisson, Agathe Mizrahi, Assaf Fournier, Damien Bonnin, Rémy A. Degand, Nicolas Morand, Philippe Janvier, Frédéric Fihman, Vincent Corvec, Stéphane Broutin, Lauranne Le Brun, Cécile Yin, Nicolas Héry-Arnaud, Geneviève Grillon, Antoine Bille, Emmanuelle Jean-Pierre, Hélène Amara, Marlène Jaureguy, Francoise Isnard, Christophe Cattoir, Vincent Diedrich, Tristan Flevin, Emilie Merens, Audrey Jacquier, Hervé Vasse, Marc |
author_facet | Farfour, Eric Dortet, Laurent Guillard, Thomas Chatelain, Nicolas Poisson, Agathe Mizrahi, Assaf Fournier, Damien Bonnin, Rémy A. Degand, Nicolas Morand, Philippe Janvier, Frédéric Fihman, Vincent Corvec, Stéphane Broutin, Lauranne Le Brun, Cécile Yin, Nicolas Héry-Arnaud, Geneviève Grillon, Antoine Bille, Emmanuelle Jean-Pierre, Hélène Amara, Marlène Jaureguy, Francoise Isnard, Christophe Cattoir, Vincent Diedrich, Tristan Flevin, Emilie Merens, Audrey Jacquier, Hervé Vasse, Marc |
author_sort | Farfour, Eric |
collection | PubMed |
description | In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in P. mirabilis to 19.5% in K. pneumoniae, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E. |
format | Online Article Text |
id | pubmed-8949168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89491682022-03-26 Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France Farfour, Eric Dortet, Laurent Guillard, Thomas Chatelain, Nicolas Poisson, Agathe Mizrahi, Assaf Fournier, Damien Bonnin, Rémy A. Degand, Nicolas Morand, Philippe Janvier, Frédéric Fihman, Vincent Corvec, Stéphane Broutin, Lauranne Le Brun, Cécile Yin, Nicolas Héry-Arnaud, Geneviève Grillon, Antoine Bille, Emmanuelle Jean-Pierre, Hélène Amara, Marlène Jaureguy, Francoise Isnard, Christophe Cattoir, Vincent Diedrich, Tristan Flevin, Emilie Merens, Audrey Jacquier, Hervé Vasse, Marc Pathogens Article In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in P. mirabilis to 19.5% in K. pneumoniae, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E. MDPI 2022-03-15 /pmc/articles/PMC8949168/ /pubmed/35335681 http://dx.doi.org/10.3390/pathogens11030356 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Farfour, Eric Dortet, Laurent Guillard, Thomas Chatelain, Nicolas Poisson, Agathe Mizrahi, Assaf Fournier, Damien Bonnin, Rémy A. Degand, Nicolas Morand, Philippe Janvier, Frédéric Fihman, Vincent Corvec, Stéphane Broutin, Lauranne Le Brun, Cécile Yin, Nicolas Héry-Arnaud, Geneviève Grillon, Antoine Bille, Emmanuelle Jean-Pierre, Hélène Amara, Marlène Jaureguy, Francoise Isnard, Christophe Cattoir, Vincent Diedrich, Tristan Flevin, Emilie Merens, Audrey Jacquier, Hervé Vasse, Marc Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France |
title | Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France |
title_full | Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France |
title_fullStr | Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France |
title_full_unstemmed | Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France |
title_short | Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France |
title_sort | antimicrobial resistance in enterobacterales recovered from urinary tract infections in france |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949168/ https://www.ncbi.nlm.nih.gov/pubmed/35335681 http://dx.doi.org/10.3390/pathogens11030356 |
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