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Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France

In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017,...

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Autores principales: Farfour, Eric, Dortet, Laurent, Guillard, Thomas, Chatelain, Nicolas, Poisson, Agathe, Mizrahi, Assaf, Fournier, Damien, Bonnin, Rémy A., Degand, Nicolas, Morand, Philippe, Janvier, Frédéric, Fihman, Vincent, Corvec, Stéphane, Broutin, Lauranne, Le Brun, Cécile, Yin, Nicolas, Héry-Arnaud, Geneviève, Grillon, Antoine, Bille, Emmanuelle, Jean-Pierre, Hélène, Amara, Marlène, Jaureguy, Francoise, Isnard, Christophe, Cattoir, Vincent, Diedrich, Tristan, Flevin, Emilie, Merens, Audrey, Jacquier, Hervé, Vasse, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949168/
https://www.ncbi.nlm.nih.gov/pubmed/35335681
http://dx.doi.org/10.3390/pathogens11030356
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author Farfour, Eric
Dortet, Laurent
Guillard, Thomas
Chatelain, Nicolas
Poisson, Agathe
Mizrahi, Assaf
Fournier, Damien
Bonnin, Rémy A.
Degand, Nicolas
Morand, Philippe
Janvier, Frédéric
Fihman, Vincent
Corvec, Stéphane
Broutin, Lauranne
Le Brun, Cécile
Yin, Nicolas
Héry-Arnaud, Geneviève
Grillon, Antoine
Bille, Emmanuelle
Jean-Pierre, Hélène
Amara, Marlène
Jaureguy, Francoise
Isnard, Christophe
Cattoir, Vincent
Diedrich, Tristan
Flevin, Emilie
Merens, Audrey
Jacquier, Hervé
Vasse, Marc
author_facet Farfour, Eric
Dortet, Laurent
Guillard, Thomas
Chatelain, Nicolas
Poisson, Agathe
Mizrahi, Assaf
Fournier, Damien
Bonnin, Rémy A.
Degand, Nicolas
Morand, Philippe
Janvier, Frédéric
Fihman, Vincent
Corvec, Stéphane
Broutin, Lauranne
Le Brun, Cécile
Yin, Nicolas
Héry-Arnaud, Geneviève
Grillon, Antoine
Bille, Emmanuelle
Jean-Pierre, Hélène
Amara, Marlène
Jaureguy, Francoise
Isnard, Christophe
Cattoir, Vincent
Diedrich, Tristan
Flevin, Emilie
Merens, Audrey
Jacquier, Hervé
Vasse, Marc
author_sort Farfour, Eric
collection PubMed
description In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in P. mirabilis to 19.5% in K. pneumoniae, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E.
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spelling pubmed-89491682022-03-26 Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France Farfour, Eric Dortet, Laurent Guillard, Thomas Chatelain, Nicolas Poisson, Agathe Mizrahi, Assaf Fournier, Damien Bonnin, Rémy A. Degand, Nicolas Morand, Philippe Janvier, Frédéric Fihman, Vincent Corvec, Stéphane Broutin, Lauranne Le Brun, Cécile Yin, Nicolas Héry-Arnaud, Geneviève Grillon, Antoine Bille, Emmanuelle Jean-Pierre, Hélène Amara, Marlène Jaureguy, Francoise Isnard, Christophe Cattoir, Vincent Diedrich, Tristan Flevin, Emilie Merens, Audrey Jacquier, Hervé Vasse, Marc Pathogens Article In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in P. mirabilis to 19.5% in K. pneumoniae, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E. MDPI 2022-03-15 /pmc/articles/PMC8949168/ /pubmed/35335681 http://dx.doi.org/10.3390/pathogens11030356 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Farfour, Eric
Dortet, Laurent
Guillard, Thomas
Chatelain, Nicolas
Poisson, Agathe
Mizrahi, Assaf
Fournier, Damien
Bonnin, Rémy A.
Degand, Nicolas
Morand, Philippe
Janvier, Frédéric
Fihman, Vincent
Corvec, Stéphane
Broutin, Lauranne
Le Brun, Cécile
Yin, Nicolas
Héry-Arnaud, Geneviève
Grillon, Antoine
Bille, Emmanuelle
Jean-Pierre, Hélène
Amara, Marlène
Jaureguy, Francoise
Isnard, Christophe
Cattoir, Vincent
Diedrich, Tristan
Flevin, Emilie
Merens, Audrey
Jacquier, Hervé
Vasse, Marc
Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France
title Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France
title_full Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France
title_fullStr Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France
title_full_unstemmed Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France
title_short Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France
title_sort antimicrobial resistance in enterobacterales recovered from urinary tract infections in france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949168/
https://www.ncbi.nlm.nih.gov/pubmed/35335681
http://dx.doi.org/10.3390/pathogens11030356
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