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Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan

The mortality and disability-adjusted life years (DALYs) of burn patients are decreasing over time. However, finding novel effective treatment approaches using natural agents is highly considered to reduce the burden of burn injuries. One of the recent agents used in wound healing is β-glucan, mainl...

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Autores principales: Abedini, Fateme, Mohammadi, Shahla Roudbar, Dahmardehei, Mostafa, Ajami, Marjan, Salimi, Maryam, Khalandi, Halala, Mohsenzadegan, Monireh, Seif, Farhad, Shirvan, Bahador Nikoueian, Yaalimadad, Sanaz, Roudbary, Maryam, Rodrigues, Célia F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949177/
https://www.ncbi.nlm.nih.gov/pubmed/35330265
http://dx.doi.org/10.3390/jof8030263
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author Abedini, Fateme
Mohammadi, Shahla Roudbar
Dahmardehei, Mostafa
Ajami, Marjan
Salimi, Maryam
Khalandi, Halala
Mohsenzadegan, Monireh
Seif, Farhad
Shirvan, Bahador Nikoueian
Yaalimadad, Sanaz
Roudbary, Maryam
Rodrigues, Célia F.
author_facet Abedini, Fateme
Mohammadi, Shahla Roudbar
Dahmardehei, Mostafa
Ajami, Marjan
Salimi, Maryam
Khalandi, Halala
Mohsenzadegan, Monireh
Seif, Farhad
Shirvan, Bahador Nikoueian
Yaalimadad, Sanaz
Roudbary, Maryam
Rodrigues, Célia F.
author_sort Abedini, Fateme
collection PubMed
description The mortality and disability-adjusted life years (DALYs) of burn patients are decreasing over time. However, finding novel effective treatment approaches using natural agents is highly considered to reduce the burden of burn injuries. One of the recent agents used in wound healing is β-glucan, mainly extracted from fungi cell walls. This study aimed to evaluate the effect of 5% (m/m) of yeast β-glucan ointment on burn wound healing and to assess the impact of β-glucan on cytokines during the treatment. Thirty-three patients with second or third-degree burns were enrolled in this study. Two groups of twenty-three and ten patients used yeast 5% (m/m) β-glucan ointment (study group) and Stratamed ointment (control), respectively, on a daily basis, for a maximum of four weeks. The size of the burn wounds was measured before and at the end of the treatment. Blood samples of 14 and 10 patients in the β-glucan and control groups, respectively, were obtained before and after the treatment, and the enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum concentration of the IL-4, IL-17, and IFN-γ cytokines. The log-binomial model was used to assess the efficacy of the β-glucan ointment on burn wound healing. ANOVA/ANCOVA was employed to assess the effects of β-glucan on the serum concentration of cytokines. After adjusting for potential confounders/covariates, patients receiving β-glucan had better wound healing (RR = 4.34; 95% CI: 0.73 to 25.67; p = 0.11). There was a significant difference in IL-4 secretion between the β-glucan and control groups after adjusting for potential confounders/covariates (MD = 77.27; 95% CI: 44.73 to 109.82; Cohen’s d = 2.21; 95% CI: 1.16 to 3.24; p = 0.0001). The results indicate that 5% (m/m) of β-glucan has efficacy in burn wound healing, and a significant difference was found in the level of IL-4 after receiving β-glucan. Further studies with a two-arm design and long-term use of ointment are needed to confirm the effect of β-glucan on wound healing and cytokine secretion.
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spelling pubmed-89491772022-03-26 Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan Abedini, Fateme Mohammadi, Shahla Roudbar Dahmardehei, Mostafa Ajami, Marjan Salimi, Maryam Khalandi, Halala Mohsenzadegan, Monireh Seif, Farhad Shirvan, Bahador Nikoueian Yaalimadad, Sanaz Roudbary, Maryam Rodrigues, Célia F. J Fungi (Basel) Article The mortality and disability-adjusted life years (DALYs) of burn patients are decreasing over time. However, finding novel effective treatment approaches using natural agents is highly considered to reduce the burden of burn injuries. One of the recent agents used in wound healing is β-glucan, mainly extracted from fungi cell walls. This study aimed to evaluate the effect of 5% (m/m) of yeast β-glucan ointment on burn wound healing and to assess the impact of β-glucan on cytokines during the treatment. Thirty-three patients with second or third-degree burns were enrolled in this study. Two groups of twenty-three and ten patients used yeast 5% (m/m) β-glucan ointment (study group) and Stratamed ointment (control), respectively, on a daily basis, for a maximum of four weeks. The size of the burn wounds was measured before and at the end of the treatment. Blood samples of 14 and 10 patients in the β-glucan and control groups, respectively, were obtained before and after the treatment, and the enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum concentration of the IL-4, IL-17, and IFN-γ cytokines. The log-binomial model was used to assess the efficacy of the β-glucan ointment on burn wound healing. ANOVA/ANCOVA was employed to assess the effects of β-glucan on the serum concentration of cytokines. After adjusting for potential confounders/covariates, patients receiving β-glucan had better wound healing (RR = 4.34; 95% CI: 0.73 to 25.67; p = 0.11). There was a significant difference in IL-4 secretion between the β-glucan and control groups after adjusting for potential confounders/covariates (MD = 77.27; 95% CI: 44.73 to 109.82; Cohen’s d = 2.21; 95% CI: 1.16 to 3.24; p = 0.0001). The results indicate that 5% (m/m) of β-glucan has efficacy in burn wound healing, and a significant difference was found in the level of IL-4 after receiving β-glucan. Further studies with a two-arm design and long-term use of ointment are needed to confirm the effect of β-glucan on wound healing and cytokine secretion. MDPI 2022-03-04 /pmc/articles/PMC8949177/ /pubmed/35330265 http://dx.doi.org/10.3390/jof8030263 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abedini, Fateme
Mohammadi, Shahla Roudbar
Dahmardehei, Mostafa
Ajami, Marjan
Salimi, Maryam
Khalandi, Halala
Mohsenzadegan, Monireh
Seif, Farhad
Shirvan, Bahador Nikoueian
Yaalimadad, Sanaz
Roudbary, Maryam
Rodrigues, Célia F.
Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan
title Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan
title_full Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan
title_fullStr Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan
title_full_unstemmed Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan
title_short Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan
title_sort enhancing of wound healing in burn patients through candida albicans β-glucan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949177/
https://www.ncbi.nlm.nih.gov/pubmed/35330265
http://dx.doi.org/10.3390/jof8030263
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