General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles

An efficient access to the novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed. The method is based on Buchwald–Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-...

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Autores principales: Gribanov, Pavel S., Philippova, Anna N., Topchiy, Maxim A., Minaeva, Lidiya I., Asachenko, Andrey F., Osipov, Sergey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949195/
https://www.ncbi.nlm.nih.gov/pubmed/35335361
http://dx.doi.org/10.3390/molecules27061999
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author Gribanov, Pavel S.
Philippova, Anna N.
Topchiy, Maxim A.
Minaeva, Lidiya I.
Asachenko, Andrey F.
Osipov, Sergey N.
author_facet Gribanov, Pavel S.
Philippova, Anna N.
Topchiy, Maxim A.
Minaeva, Lidiya I.
Asachenko, Andrey F.
Osipov, Sergey N.
author_sort Gribanov, Pavel S.
collection PubMed
description An efficient access to the novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed. The method is based on Buchwald–Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-Dipp)Pd(cinn)Cl] bearing expanded-ring N-heterocyclic carbene ligand is the most active catalyst for the process to afford the target molecules in high yields.
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spelling pubmed-89491952022-03-26 General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles Gribanov, Pavel S. Philippova, Anna N. Topchiy, Maxim A. Minaeva, Lidiya I. Asachenko, Andrey F. Osipov, Sergey N. Molecules Article An efficient access to the novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed. The method is based on Buchwald–Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-Dipp)Pd(cinn)Cl] bearing expanded-ring N-heterocyclic carbene ligand is the most active catalyst for the process to afford the target molecules in high yields. MDPI 2022-03-20 /pmc/articles/PMC8949195/ /pubmed/35335361 http://dx.doi.org/10.3390/molecules27061999 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gribanov, Pavel S.
Philippova, Anna N.
Topchiy, Maxim A.
Minaeva, Lidiya I.
Asachenko, Andrey F.
Osipov, Sergey N.
General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles
title General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles
title_full General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles
title_fullStr General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles
title_full_unstemmed General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles
title_short General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles
title_sort general method of synthesis of 5-(het)arylamino-1,2,3-triazoles via buchwald–hartwig reaction of 5-amino- or 5-halo-1,2,3-triazoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949195/
https://www.ncbi.nlm.nih.gov/pubmed/35335361
http://dx.doi.org/10.3390/molecules27061999
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