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Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy

The PRIMATE study is an Italian translational research project, which aims to identify personalized biomarkers associated with clinical characteristics of malignant pleural mesothelioma (MPM). For this purpose, characteristics of MPM patients with different degrees of asbestos exposure will be compa...

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Autores principales: Spinazzè, Andrea, Consonni, Dario, Borghi, Francesca, Rovelli, Sabrina, Cattaneo, Andrea, Zellino, Carolina, Dallari, Barbara, Pesatori, Angela Cecilia, Kromhout, Hans, Peters, Susan, Riboldi, Luciano, Cavallo, Domenico Maria, Mensi, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949216/
https://www.ncbi.nlm.nih.gov/pubmed/35329075
http://dx.doi.org/10.3390/ijerph19063390
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author Spinazzè, Andrea
Consonni, Dario
Borghi, Francesca
Rovelli, Sabrina
Cattaneo, Andrea
Zellino, Carolina
Dallari, Barbara
Pesatori, Angela Cecilia
Kromhout, Hans
Peters, Susan
Riboldi, Luciano
Cavallo, Domenico Maria
Mensi, Carolina
author_facet Spinazzè, Andrea
Consonni, Dario
Borghi, Francesca
Rovelli, Sabrina
Cattaneo, Andrea
Zellino, Carolina
Dallari, Barbara
Pesatori, Angela Cecilia
Kromhout, Hans
Peters, Susan
Riboldi, Luciano
Cavallo, Domenico Maria
Mensi, Carolina
author_sort Spinazzè, Andrea
collection PubMed
description The PRIMATE study is an Italian translational research project, which aims to identify personalized biomarkers associated with clinical characteristics of malignant pleural mesothelioma (MPM). For this purpose, characteristics of MPM patients with different degrees of asbestos exposure will be compared to identify somatic mutations, germline polymorphism, and blood inflammatory biomarkers. In this framework, we assessed exposure to asbestos for 562 cases of MPM extracted from the Lombardy region Mesothelioma Registry (RML), for which a complete interview based on a standardized national questionnaire and histopathological specimens were available. Exposure assessment was performed: (1) through experts' evaluation (considered as the gold standard for the purpose of this study), according to the guidelines of the Italian National Mesothelioma Registry (ReNaM) and (2) using a job-exposure matrix (SYN-JEM) to obtain qualitative (ever/never) and quantitative estimates of occupational asbestos exposure (cumulative exposure expressed in fibers per mL (f/mL)). The performance of SYN-JEM was evaluated against the experts' evaluation. According to experts' evaluation, occupational asbestos exposure was recognized in 73.6% of men and 23.6% of women; furthermore, 29 men (7.8%) and 70 women (36.9%) had non-occupational exposure to asbestos. When applying SYN-JEM, 225 men (60.5%) and 25 women (13.2%) were classified as occupationally exposed, with a median cumulative exposure higher for men (1.7 f/mL-years) than for women (1.2 f/mL-years). The concordance between the two methods (Cohen’s kappa) for occupational exposure assessment was 0.46 overall (0.41 in men, and 0.07 in women). Sensitivity was higher in men (0.73) than in women (0.18), while specificity was higher in women (0.88) than in men (0.74). Overall, both methods can be used to reconstruct past occupational exposure to asbestos, each with its own advantages and limitations.
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spelling pubmed-89492162022-03-26 Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy Spinazzè, Andrea Consonni, Dario Borghi, Francesca Rovelli, Sabrina Cattaneo, Andrea Zellino, Carolina Dallari, Barbara Pesatori, Angela Cecilia Kromhout, Hans Peters, Susan Riboldi, Luciano Cavallo, Domenico Maria Mensi, Carolina Int J Environ Res Public Health Article The PRIMATE study is an Italian translational research project, which aims to identify personalized biomarkers associated with clinical characteristics of malignant pleural mesothelioma (MPM). For this purpose, characteristics of MPM patients with different degrees of asbestos exposure will be compared to identify somatic mutations, germline polymorphism, and blood inflammatory biomarkers. In this framework, we assessed exposure to asbestos for 562 cases of MPM extracted from the Lombardy region Mesothelioma Registry (RML), for which a complete interview based on a standardized national questionnaire and histopathological specimens were available. Exposure assessment was performed: (1) through experts' evaluation (considered as the gold standard for the purpose of this study), according to the guidelines of the Italian National Mesothelioma Registry (ReNaM) and (2) using a job-exposure matrix (SYN-JEM) to obtain qualitative (ever/never) and quantitative estimates of occupational asbestos exposure (cumulative exposure expressed in fibers per mL (f/mL)). The performance of SYN-JEM was evaluated against the experts' evaluation. According to experts' evaluation, occupational asbestos exposure was recognized in 73.6% of men and 23.6% of women; furthermore, 29 men (7.8%) and 70 women (36.9%) had non-occupational exposure to asbestos. When applying SYN-JEM, 225 men (60.5%) and 25 women (13.2%) were classified as occupationally exposed, with a median cumulative exposure higher for men (1.7 f/mL-years) than for women (1.2 f/mL-years). The concordance between the two methods (Cohen’s kappa) for occupational exposure assessment was 0.46 overall (0.41 in men, and 0.07 in women). Sensitivity was higher in men (0.73) than in women (0.18), while specificity was higher in women (0.88) than in men (0.74). Overall, both methods can be used to reconstruct past occupational exposure to asbestos, each with its own advantages and limitations. MDPI 2022-03-13 /pmc/articles/PMC8949216/ /pubmed/35329075 http://dx.doi.org/10.3390/ijerph19063390 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spinazzè, Andrea
Consonni, Dario
Borghi, Francesca
Rovelli, Sabrina
Cattaneo, Andrea
Zellino, Carolina
Dallari, Barbara
Pesatori, Angela Cecilia
Kromhout, Hans
Peters, Susan
Riboldi, Luciano
Cavallo, Domenico Maria
Mensi, Carolina
Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy
title Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy
title_full Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy
title_fullStr Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy
title_full_unstemmed Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy
title_short Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy
title_sort asbestos exposure in patients with malignant pleural mesothelioma included in the primate study, lombardy, italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949216/
https://www.ncbi.nlm.nih.gov/pubmed/35329075
http://dx.doi.org/10.3390/ijerph19063390
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