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Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array
A continuous blood glucose monitoring system (CGMS) which include a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device is developed in this research. When in use, the wearable device is attached to the human body with the microneedle array...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949222/ https://www.ncbi.nlm.nih.gov/pubmed/35334773 http://dx.doi.org/10.3390/mi13030478 |
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author | Chien, Ming-Nan Chen, Yu-Jen Bai, Chin-Han Huang, Jung-Tung |
author_facet | Chien, Ming-Nan Chen, Yu-Jen Bai, Chin-Han Huang, Jung-Tung |
author_sort | Chien, Ming-Nan |
collection | PubMed |
description | A continuous blood glucose monitoring system (CGMS) which include a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device is developed in this research. When in use, the wearable device is attached to the human body with the microneedle array inserted under the skin for continuous blood glucose sensing, and the measured signals are transmitted wirelessly to a mobile phone or computer for analysis. The purpose of this study is to replace the conventionally used method of puncture for blood collection and test strips are used to measure the blood glucose signals. The microneedle sensor of this CGMS uses a 1 mm length needle in a 3 mm × 3 mm microneedle array for percutaneous minimally invasive blood glucose measurement. This size of microneedle does not cause bleeding damage to the body when used. The microneedle sensor is placed under the skin and their solutions are discussed. The blood glucose sensor measured the in vitro simulant fluid with a glucose concentration range of 50~400 mg/dL. In addition, a micro-transfer method is developed to accurately deposit the enzyme onto the tip of the microneedle, after which cyclic voltammetry (CV) is used to measure the glucose simulation solution to verify whether the difference in the amount of enzyme on each microneedle is less than 10%. Finally, various experiments and analyses are carried out to reduce the size of the device, test effective durability (approximately 7 days), and the feasibility of minimally invasive CGMS is evaluated by tests on two persons. |
format | Online Article Text |
id | pubmed-8949222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89492222022-03-26 Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array Chien, Ming-Nan Chen, Yu-Jen Bai, Chin-Han Huang, Jung-Tung Micromachines (Basel) Article A continuous blood glucose monitoring system (CGMS) which include a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device is developed in this research. When in use, the wearable device is attached to the human body with the microneedle array inserted under the skin for continuous blood glucose sensing, and the measured signals are transmitted wirelessly to a mobile phone or computer for analysis. The purpose of this study is to replace the conventionally used method of puncture for blood collection and test strips are used to measure the blood glucose signals. The microneedle sensor of this CGMS uses a 1 mm length needle in a 3 mm × 3 mm microneedle array for percutaneous minimally invasive blood glucose measurement. This size of microneedle does not cause bleeding damage to the body when used. The microneedle sensor is placed under the skin and their solutions are discussed. The blood glucose sensor measured the in vitro simulant fluid with a glucose concentration range of 50~400 mg/dL. In addition, a micro-transfer method is developed to accurately deposit the enzyme onto the tip of the microneedle, after which cyclic voltammetry (CV) is used to measure the glucose simulation solution to verify whether the difference in the amount of enzyme on each microneedle is less than 10%. Finally, various experiments and analyses are carried out to reduce the size of the device, test effective durability (approximately 7 days), and the feasibility of minimally invasive CGMS is evaluated by tests on two persons. MDPI 2022-03-20 /pmc/articles/PMC8949222/ /pubmed/35334773 http://dx.doi.org/10.3390/mi13030478 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chien, Ming-Nan Chen, Yu-Jen Bai, Chin-Han Huang, Jung-Tung Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array |
title | Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array |
title_full | Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array |
title_fullStr | Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array |
title_full_unstemmed | Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array |
title_short | Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array |
title_sort | continuous glucose monitoring system based on percutaneous microneedle array |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949222/ https://www.ncbi.nlm.nih.gov/pubmed/35334773 http://dx.doi.org/10.3390/mi13030478 |
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