COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients

Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with sever...

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Detalles Bibliográficos
Autores principales: Angioni, Roberta, Sasset, Lolita, Cioccarelli, Chiara, Sánchez-Rodríguez, Ricardo, Bertoldi, Nicole, Putaggio, Cristina C., Viola, Antonella, Cattelan, Annamaria, Molon, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949226/
https://www.ncbi.nlm.nih.gov/pubmed/35336973
http://dx.doi.org/10.3390/v14030565
Descripción
Sumario:Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1ß and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), in vaccinated patients as compared to non-vaccinated ones. COVID-19 vaccination indeed prevents severe clinical manifestations in patients and limits the release of systemic danger signals in SARS-CoV-2 infected people.

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