COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients

Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with sever...

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Autores principales: Angioni, Roberta, Sasset, Lolita, Cioccarelli, Chiara, Sánchez-Rodríguez, Ricardo, Bertoldi, Nicole, Putaggio, Cristina C., Viola, Antonella, Cattelan, Annamaria, Molon, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949226/
https://www.ncbi.nlm.nih.gov/pubmed/35336973
http://dx.doi.org/10.3390/v14030565
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author Angioni, Roberta
Sasset, Lolita
Cioccarelli, Chiara
Sánchez-Rodríguez, Ricardo
Bertoldi, Nicole
Putaggio, Cristina C.
Viola, Antonella
Cattelan, Annamaria
Molon, Barbara
author_facet Angioni, Roberta
Sasset, Lolita
Cioccarelli, Chiara
Sánchez-Rodríguez, Ricardo
Bertoldi, Nicole
Putaggio, Cristina C.
Viola, Antonella
Cattelan, Annamaria
Molon, Barbara
author_sort Angioni, Roberta
collection PubMed
description Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1ß and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), in vaccinated patients as compared to non-vaccinated ones. COVID-19 vaccination indeed prevents severe clinical manifestations in patients and limits the release of systemic danger signals in SARS-CoV-2 infected people.
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spelling pubmed-89492262022-03-26 COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients Angioni, Roberta Sasset, Lolita Cioccarelli, Chiara Sánchez-Rodríguez, Ricardo Bertoldi, Nicole Putaggio, Cristina C. Viola, Antonella Cattelan, Annamaria Molon, Barbara Viruses Brief Report Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1ß and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), in vaccinated patients as compared to non-vaccinated ones. COVID-19 vaccination indeed prevents severe clinical manifestations in patients and limits the release of systemic danger signals in SARS-CoV-2 infected people. MDPI 2022-03-09 /pmc/articles/PMC8949226/ /pubmed/35336973 http://dx.doi.org/10.3390/v14030565 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Angioni, Roberta
Sasset, Lolita
Cioccarelli, Chiara
Sánchez-Rodríguez, Ricardo
Bertoldi, Nicole
Putaggio, Cristina C.
Viola, Antonella
Cattelan, Annamaria
Molon, Barbara
COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients
title COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients
title_full COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients
title_fullStr COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients
title_full_unstemmed COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients
title_short COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients
title_sort covid-19 vaccination limits systemic danger signals in sars-cov-2 infected patients
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949226/
https://www.ncbi.nlm.nih.gov/pubmed/35336973
http://dx.doi.org/10.3390/v14030565
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