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Role of Cholinergic Signaling in Alzheimer’s Disease

Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), a progressive and commonly diagnosed neurodegenerative disease, is characterized by memory and cognitive decline and behavioral diso...

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Autores principales: Chen, Zhi-Ru, Huang, Jia-Bao, Yang, Shu-Long, Hong, Fen-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949236/
https://www.ncbi.nlm.nih.gov/pubmed/35335180
http://dx.doi.org/10.3390/molecules27061816
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author Chen, Zhi-Ru
Huang, Jia-Bao
Yang, Shu-Long
Hong, Fen-Fang
author_facet Chen, Zhi-Ru
Huang, Jia-Bao
Yang, Shu-Long
Hong, Fen-Fang
author_sort Chen, Zhi-Ru
collection PubMed
description Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), a progressive and commonly diagnosed neurodegenerative disease, is characterized by memory and cognitive decline and behavioral disorders. The pathogenesis of AD is complex and remains unclear, being affected by various factors. The cholinergic hypothesis is the earliest theory about the pathogenesis of AD. Cholinergic atrophy and cognitive decline are accelerated in age-related neurodegenerative diseases such as AD. In addition, abnormal central cholinergic changes can also induce abnormal phosphorylation of ttau protein, nerve cell inflammation, cell apoptosis, and other pathological phenomena, but the exact mechanism of action is still unclear. Due to the complex and unclear pathogenesis, effective methods to prevent and treat AD are unavailable, and research to explore novel therapeutic drugs is various and active in the world. This review summaries the role of cholinergic signaling and the correlation between the cholinergic signaling pathway with other risk factors in AD and provides the latest research about the efficient therapeutic drugs and treatment of AD.
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spelling pubmed-89492362022-03-26 Role of Cholinergic Signaling in Alzheimer’s Disease Chen, Zhi-Ru Huang, Jia-Bao Yang, Shu-Long Hong, Fen-Fang Molecules Review Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), a progressive and commonly diagnosed neurodegenerative disease, is characterized by memory and cognitive decline and behavioral disorders. The pathogenesis of AD is complex and remains unclear, being affected by various factors. The cholinergic hypothesis is the earliest theory about the pathogenesis of AD. Cholinergic atrophy and cognitive decline are accelerated in age-related neurodegenerative diseases such as AD. In addition, abnormal central cholinergic changes can also induce abnormal phosphorylation of ttau protein, nerve cell inflammation, cell apoptosis, and other pathological phenomena, but the exact mechanism of action is still unclear. Due to the complex and unclear pathogenesis, effective methods to prevent and treat AD are unavailable, and research to explore novel therapeutic drugs is various and active in the world. This review summaries the role of cholinergic signaling and the correlation between the cholinergic signaling pathway with other risk factors in AD and provides the latest research about the efficient therapeutic drugs and treatment of AD. MDPI 2022-03-10 /pmc/articles/PMC8949236/ /pubmed/35335180 http://dx.doi.org/10.3390/molecules27061816 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Zhi-Ru
Huang, Jia-Bao
Yang, Shu-Long
Hong, Fen-Fang
Role of Cholinergic Signaling in Alzheimer’s Disease
title Role of Cholinergic Signaling in Alzheimer’s Disease
title_full Role of Cholinergic Signaling in Alzheimer’s Disease
title_fullStr Role of Cholinergic Signaling in Alzheimer’s Disease
title_full_unstemmed Role of Cholinergic Signaling in Alzheimer’s Disease
title_short Role of Cholinergic Signaling in Alzheimer’s Disease
title_sort role of cholinergic signaling in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949236/
https://www.ncbi.nlm.nih.gov/pubmed/35335180
http://dx.doi.org/10.3390/molecules27061816
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