Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)

Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic amino moiety (2-aza-bicyclo[2.2.1]heptane) were designed using molecular modelling methods, synthesised, and found to be potent DPP-4 (dipeptidyl peptidase-4) inhibitors. Compound 12a (IC50 = 16.8 ± 2...

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Detalles Bibliográficos
Autores principales: Maslov, Ivan O., Zinevich, Tatiana V., Kirichenko, Olga G., Trukhan, Mikhail V., Shorshnev, Sergey V., Tuaeva, Natalya O., Gureev, Maxim A., Dahlén, Amelia D., Porozov, Yuri B., Schiöth, Helgi B., Trukhan, Vladimir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949241/
https://www.ncbi.nlm.nih.gov/pubmed/35337071
http://dx.doi.org/10.3390/ph15030273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949241/
https://www.ncbi.nlm.nih.gov/pubmed/35337071
http://dx.doi.org/10.3390/ph15030273

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