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Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults

The optimal blood pressure (BP) target in older people according to frailty status remains uncertain. This article investigates how frailty affects the association between BP and cardiovascular diseases or mortality, specifically in young-old adults. A retrospective cohort was created for 708,964 ol...

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Autores principales: Chun, Sohyun, Han, Kyungdo, Lee, Seungwoo, Cho, Mi-Hee, Jeong, Su-Min, Jung, Hee-Won, Son, Ki-Young, Shin, Dong-Wook, Lee, Sang-Chol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949292/
https://www.ncbi.nlm.nih.gov/pubmed/35330418
http://dx.doi.org/10.3390/jpm12030418
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author Chun, Sohyun
Han, Kyungdo
Lee, Seungwoo
Cho, Mi-Hee
Jeong, Su-Min
Jung, Hee-Won
Son, Ki-Young
Shin, Dong-Wook
Lee, Sang-Chol
author_facet Chun, Sohyun
Han, Kyungdo
Lee, Seungwoo
Cho, Mi-Hee
Jeong, Su-Min
Jung, Hee-Won
Son, Ki-Young
Shin, Dong-Wook
Lee, Sang-Chol
author_sort Chun, Sohyun
collection PubMed
description The optimal blood pressure (BP) target in older people according to frailty status remains uncertain. This article investigates how frailty affects the association between BP and cardiovascular diseases or mortality, specifically in young-old adults. A retrospective cohort was created for 708,964 older adults with a uniform age of 66 years. The association between BP and myocardial infarction (MI), stroke, or mortality was analyzed using Cox proportional hazards models. The Timed Up and Go test (TUG) was used as a measure of physical frailty. Mean follow-up was 6.8 years, detecting 38,963 (5.5%) events. There was a linear association between increasing systolic BP (SBP) or diastolic BP (DBP) and increased risk of incident MI and stroke, compared to the reference BP (SBP, 110–119 mmHg or DBP, 80–89 mmHg). The risk patterns with high BP remained similar in each TUG group (<10, 10–14, or ≥15 s). A similar pattern of increased risks was found in those who took antihypertensive drugs and who did not, however they were more pronounced in those who did not. The findings support the need to achieve the same BP target in young-old adults with or without frailty to lower the risk of MI, stroke, and mortality.
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spelling pubmed-89492922022-03-26 Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults Chun, Sohyun Han, Kyungdo Lee, Seungwoo Cho, Mi-Hee Jeong, Su-Min Jung, Hee-Won Son, Ki-Young Shin, Dong-Wook Lee, Sang-Chol J Pers Med Article The optimal blood pressure (BP) target in older people according to frailty status remains uncertain. This article investigates how frailty affects the association between BP and cardiovascular diseases or mortality, specifically in young-old adults. A retrospective cohort was created for 708,964 older adults with a uniform age of 66 years. The association between BP and myocardial infarction (MI), stroke, or mortality was analyzed using Cox proportional hazards models. The Timed Up and Go test (TUG) was used as a measure of physical frailty. Mean follow-up was 6.8 years, detecting 38,963 (5.5%) events. There was a linear association between increasing systolic BP (SBP) or diastolic BP (DBP) and increased risk of incident MI and stroke, compared to the reference BP (SBP, 110–119 mmHg or DBP, 80–89 mmHg). The risk patterns with high BP remained similar in each TUG group (<10, 10–14, or ≥15 s). A similar pattern of increased risks was found in those who took antihypertensive drugs and who did not, however they were more pronounced in those who did not. The findings support the need to achieve the same BP target in young-old adults with or without frailty to lower the risk of MI, stroke, and mortality. MDPI 2022-03-08 /pmc/articles/PMC8949292/ /pubmed/35330418 http://dx.doi.org/10.3390/jpm12030418 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chun, Sohyun
Han, Kyungdo
Lee, Seungwoo
Cho, Mi-Hee
Jeong, Su-Min
Jung, Hee-Won
Son, Ki-Young
Shin, Dong-Wook
Lee, Sang-Chol
Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults
title Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults
title_full Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults
title_fullStr Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults
title_full_unstemmed Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults
title_short Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults
title_sort impact of frailty on the relationship between blood pressure and cardiovascular diseases and mortality in young-old adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949292/
https://www.ncbi.nlm.nih.gov/pubmed/35330418
http://dx.doi.org/10.3390/jpm12030418
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