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Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis

Objective: Cardiovascular effects of thyroid hormones may be measured through heart rate variability (HRV). We sought to determine the impact of hyperthyroidism on HRV. Design: A systematic review and meta-analysis on the impact of hyperthyroidism on HRV. Methods: PubMed, Cochrane, Embase and Google...

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Autores principales: Brusseau, Valentin, Tauveron, Igor, Bagheri, Reza, Ugbolue, Ukadike Chris, Magnon, Valentin, Bouillon-Minois, Jean-Baptiste, Navel, Valentin, Dutheil, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949365/
https://www.ncbi.nlm.nih.gov/pubmed/35329294
http://dx.doi.org/10.3390/ijerph19063606
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author Brusseau, Valentin
Tauveron, Igor
Bagheri, Reza
Ugbolue, Ukadike Chris
Magnon, Valentin
Bouillon-Minois, Jean-Baptiste
Navel, Valentin
Dutheil, Frédéric
author_facet Brusseau, Valentin
Tauveron, Igor
Bagheri, Reza
Ugbolue, Ukadike Chris
Magnon, Valentin
Bouillon-Minois, Jean-Baptiste
Navel, Valentin
Dutheil, Frédéric
author_sort Brusseau, Valentin
collection PubMed
description Objective: Cardiovascular effects of thyroid hormones may be measured through heart rate variability (HRV). We sought to determine the impact of hyperthyroidism on HRV. Design: A systematic review and meta-analysis on the impact of hyperthyroidism on HRV. Methods: PubMed, Cochrane, Embase and Google Scholar were searched until 20 August 2021 for articles reporting HRV parameters in untreated hyperthyroidism and healthy controls. Random-effects meta-analysis was stratified by degree of hyperthyroidism for each HRV parameter: RR intervals (or Normal-to-Normal intervals—NN), SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50 ms of variation), total power (TP), LFnu (low-frequency normalized unit) and HFnu (high-frequency), VLF (very low-frequency), and LF/HF ratio. Results: We included 22 studies with 10,811 patients: 1002 with hyperthyroidism and 9809 healthy controls. There was a decrease in RR (effect size = −4.63, 95% CI −5.7 to −3.56), SDNN (−6.07, −7.42 to −4.71), RMSSD (−1.52, −2.18 to −0.87), pNN50 (−1.36, −1.83 to −0.88), TP (−2.05, −2.87 to −1.24), HFnu (−3.51, −4.76 to −2.26), and VLF power (−2.65, −3.74 to −1.55), and an increase in LFnu (2.66, 1.55 to 3.78) and LF/HF ratio (1.75, 1.02 to 2.48) (p < 0.01). Most parameters had ES that was twice as high in overt compared to subclinical hyperthyroidism. Increased peripheral thyroid hormones and decreased TSH levels were associated with lower RR intervals. Conclusions: Hyperthyroidism is associated with a decreased HRV, which may be explained by the deleterious effect of thyroid hormones and TSH. The increased sympathetic and decreased parasympathetic activity may have clinical implications.
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spelling pubmed-89493652022-03-26 Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis Brusseau, Valentin Tauveron, Igor Bagheri, Reza Ugbolue, Ukadike Chris Magnon, Valentin Bouillon-Minois, Jean-Baptiste Navel, Valentin Dutheil, Frédéric Int J Environ Res Public Health Systematic Review Objective: Cardiovascular effects of thyroid hormones may be measured through heart rate variability (HRV). We sought to determine the impact of hyperthyroidism on HRV. Design: A systematic review and meta-analysis on the impact of hyperthyroidism on HRV. Methods: PubMed, Cochrane, Embase and Google Scholar were searched until 20 August 2021 for articles reporting HRV parameters in untreated hyperthyroidism and healthy controls. Random-effects meta-analysis was stratified by degree of hyperthyroidism for each HRV parameter: RR intervals (or Normal-to-Normal intervals—NN), SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50 ms of variation), total power (TP), LFnu (low-frequency normalized unit) and HFnu (high-frequency), VLF (very low-frequency), and LF/HF ratio. Results: We included 22 studies with 10,811 patients: 1002 with hyperthyroidism and 9809 healthy controls. There was a decrease in RR (effect size = −4.63, 95% CI −5.7 to −3.56), SDNN (−6.07, −7.42 to −4.71), RMSSD (−1.52, −2.18 to −0.87), pNN50 (−1.36, −1.83 to −0.88), TP (−2.05, −2.87 to −1.24), HFnu (−3.51, −4.76 to −2.26), and VLF power (−2.65, −3.74 to −1.55), and an increase in LFnu (2.66, 1.55 to 3.78) and LF/HF ratio (1.75, 1.02 to 2.48) (p < 0.01). Most parameters had ES that was twice as high in overt compared to subclinical hyperthyroidism. Increased peripheral thyroid hormones and decreased TSH levels were associated with lower RR intervals. Conclusions: Hyperthyroidism is associated with a decreased HRV, which may be explained by the deleterious effect of thyroid hormones and TSH. The increased sympathetic and decreased parasympathetic activity may have clinical implications. MDPI 2022-03-18 /pmc/articles/PMC8949365/ /pubmed/35329294 http://dx.doi.org/10.3390/ijerph19063606 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Brusseau, Valentin
Tauveron, Igor
Bagheri, Reza
Ugbolue, Ukadike Chris
Magnon, Valentin
Bouillon-Minois, Jean-Baptiste
Navel, Valentin
Dutheil, Frédéric
Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis
title Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis
title_full Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis
title_fullStr Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis
title_full_unstemmed Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis
title_short Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis
title_sort heart rate variability in hyperthyroidism: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949365/
https://www.ncbi.nlm.nih.gov/pubmed/35329294
http://dx.doi.org/10.3390/ijerph19063606
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