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A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder without a known cure. Current standard-of-care treatments focus on addressing core symptoms directly but have provided limited benefits. In many cases, individuals with ASD have abnormalities in multiple organs, including the br...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949394/ https://www.ncbi.nlm.nih.gov/pubmed/35330464 http://dx.doi.org/10.3390/jpm12030464 |
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author | Frye, Richard E. |
author_facet | Frye, Richard E. |
author_sort | Frye, Richard E. |
collection | PubMed |
description | Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder without a known cure. Current standard-of-care treatments focus on addressing core symptoms directly but have provided limited benefits. In many cases, individuals with ASD have abnormalities in multiple organs, including the brain, immune and gastrointestinal system, and multiple physiological systems including redox and metabolic systems. Additionally, multiple aspects of the environment can adversely affect children with ASD including the sensory environment, psychosocial stress, dietary limitations and exposures to allergens and toxicants. Although it is not clear whether these medical abnormalities and environmental factors are related to the etiology of ASD, there is evidence that many of these factors can modulate ASD symptoms, making them a potential treatment target for improving core and associated ASD-related symptoms and improving functional limitation. Additionally, addressing underlying biological disturbances that drive pathophysiology has the potential to be disease modifying. This article describes a systematic approach using clinical history and biomarkers to personalize medical treatment for children with ASD. This approach is medically comprehensive, making it attractive for a multidisciplinary approach. By concentrating on treatable conditions in ASD, it is possible to improve functional ability and quality of life, thus providing optimal outcomes. |
format | Online Article Text |
id | pubmed-8949394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89493942022-03-26 A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder Frye, Richard E. J Pers Med Review Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder without a known cure. Current standard-of-care treatments focus on addressing core symptoms directly but have provided limited benefits. In many cases, individuals with ASD have abnormalities in multiple organs, including the brain, immune and gastrointestinal system, and multiple physiological systems including redox and metabolic systems. Additionally, multiple aspects of the environment can adversely affect children with ASD including the sensory environment, psychosocial stress, dietary limitations and exposures to allergens and toxicants. Although it is not clear whether these medical abnormalities and environmental factors are related to the etiology of ASD, there is evidence that many of these factors can modulate ASD symptoms, making them a potential treatment target for improving core and associated ASD-related symptoms and improving functional limitation. Additionally, addressing underlying biological disturbances that drive pathophysiology has the potential to be disease modifying. This article describes a systematic approach using clinical history and biomarkers to personalize medical treatment for children with ASD. This approach is medically comprehensive, making it attractive for a multidisciplinary approach. By concentrating on treatable conditions in ASD, it is possible to improve functional ability and quality of life, thus providing optimal outcomes. MDPI 2022-03-14 /pmc/articles/PMC8949394/ /pubmed/35330464 http://dx.doi.org/10.3390/jpm12030464 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Frye, Richard E. A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder |
title | A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder |
title_full | A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder |
title_fullStr | A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder |
title_full_unstemmed | A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder |
title_short | A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder |
title_sort | personalized multidisciplinary approach to evaluating and treating autism spectrum disorder |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949394/ https://www.ncbi.nlm.nih.gov/pubmed/35330464 http://dx.doi.org/10.3390/jpm12030464 |
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