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Silk Fibroin-Based Therapeutics for Impaired Wound Healing

Impaired wound healing can lead to local hypoxia or tissue necrosis and ultimately result in amputation or even death. Various factors can influence the wound healing environment, including bacterial or fungal infections, different disease states, desiccation, edema, and even systemic viral infectio...

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Autores principales: Lehmann, Tanner, Vaughn, Alyssa E., Seal, Sudipta, Liechty, Kenneth W., Zgheib, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949428/
https://www.ncbi.nlm.nih.gov/pubmed/35336024
http://dx.doi.org/10.3390/pharmaceutics14030651
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author Lehmann, Tanner
Vaughn, Alyssa E.
Seal, Sudipta
Liechty, Kenneth W.
Zgheib, Carlos
author_facet Lehmann, Tanner
Vaughn, Alyssa E.
Seal, Sudipta
Liechty, Kenneth W.
Zgheib, Carlos
author_sort Lehmann, Tanner
collection PubMed
description Impaired wound healing can lead to local hypoxia or tissue necrosis and ultimately result in amputation or even death. Various factors can influence the wound healing environment, including bacterial or fungal infections, different disease states, desiccation, edema, and even systemic viral infections such as COVID-19. Silk fibroin, the fibrous structural-protein component in silk, has emerged as a promising treatment for these impaired processes by promoting functional tissue regeneration. Silk fibroin’s dynamic properties allow for customizable nanoarchitectures, which can be tailored for effectively treating several wound healing impairments. Different forms of silk fibroin include nanoparticles, biosensors, tissue scaffolds, wound dressings, and novel drug-delivery systems. Silk fibroin can be combined with other biomaterials, such as chitosan or microRNA-bound cerium oxide nanoparticles (CNP), to have a synergistic effect on improving impaired wound healing. This review focuses on the different applications of silk-fibroin-based nanotechnology in improving the wound healing process; here we discuss silk fibroin as a tissue scaffold, topical solution, biosensor, and nanoparticle.
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spelling pubmed-89494282022-03-26 Silk Fibroin-Based Therapeutics for Impaired Wound Healing Lehmann, Tanner Vaughn, Alyssa E. Seal, Sudipta Liechty, Kenneth W. Zgheib, Carlos Pharmaceutics Review Impaired wound healing can lead to local hypoxia or tissue necrosis and ultimately result in amputation or even death. Various factors can influence the wound healing environment, including bacterial or fungal infections, different disease states, desiccation, edema, and even systemic viral infections such as COVID-19. Silk fibroin, the fibrous structural-protein component in silk, has emerged as a promising treatment for these impaired processes by promoting functional tissue regeneration. Silk fibroin’s dynamic properties allow for customizable nanoarchitectures, which can be tailored for effectively treating several wound healing impairments. Different forms of silk fibroin include nanoparticles, biosensors, tissue scaffolds, wound dressings, and novel drug-delivery systems. Silk fibroin can be combined with other biomaterials, such as chitosan or microRNA-bound cerium oxide nanoparticles (CNP), to have a synergistic effect on improving impaired wound healing. This review focuses on the different applications of silk-fibroin-based nanotechnology in improving the wound healing process; here we discuss silk fibroin as a tissue scaffold, topical solution, biosensor, and nanoparticle. MDPI 2022-03-16 /pmc/articles/PMC8949428/ /pubmed/35336024 http://dx.doi.org/10.3390/pharmaceutics14030651 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lehmann, Tanner
Vaughn, Alyssa E.
Seal, Sudipta
Liechty, Kenneth W.
Zgheib, Carlos
Silk Fibroin-Based Therapeutics for Impaired Wound Healing
title Silk Fibroin-Based Therapeutics for Impaired Wound Healing
title_full Silk Fibroin-Based Therapeutics for Impaired Wound Healing
title_fullStr Silk Fibroin-Based Therapeutics for Impaired Wound Healing
title_full_unstemmed Silk Fibroin-Based Therapeutics for Impaired Wound Healing
title_short Silk Fibroin-Based Therapeutics for Impaired Wound Healing
title_sort silk fibroin-based therapeutics for impaired wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949428/
https://www.ncbi.nlm.nih.gov/pubmed/35336024
http://dx.doi.org/10.3390/pharmaceutics14030651
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