The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response

Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological imp...

Descripción completa

Detalles Bibliográficos
Autores principales: Daks, Alexandra, Vasileva, Elena, Fedorova, Olga, Shuvalov, Oleg, Barlev, Nickolai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949485/
https://www.ncbi.nlm.nih.gov/pubmed/35330113
http://dx.doi.org/10.3390/life12030362
_version_ 1784674907692466176
author Daks, Alexandra
Vasileva, Elena
Fedorova, Olga
Shuvalov, Oleg
Barlev, Nickolai A.
author_facet Daks, Alexandra
Vasileva, Elena
Fedorova, Olga
Shuvalov, Oleg
Barlev, Nickolai A.
author_sort Daks, Alexandra
collection PubMed
description Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response.
format Online
Article
Text
id pubmed-8949485
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89494852022-03-26 The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response Daks, Alexandra Vasileva, Elena Fedorova, Olga Shuvalov, Oleg Barlev, Nickolai A. Life (Basel) Review Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response. MDPI 2022-03-02 /pmc/articles/PMC8949485/ /pubmed/35330113 http://dx.doi.org/10.3390/life12030362 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Daks, Alexandra
Vasileva, Elena
Fedorova, Olga
Shuvalov, Oleg
Barlev, Nickolai A.
The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
title The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
title_full The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
title_fullStr The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
title_full_unstemmed The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
title_short The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
title_sort role of lysine methyltransferase set7/9 in proliferation and cell stress response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949485/
https://www.ncbi.nlm.nih.gov/pubmed/35330113
http://dx.doi.org/10.3390/life12030362
work_keys_str_mv AT daksalexandra theroleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT vasilevaelena theroleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT fedorovaolga theroleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT shuvalovoleg theroleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT barlevnickolaia theroleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT daksalexandra roleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT vasilevaelena roleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT fedorovaolga roleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT shuvalovoleg roleoflysinemethyltransferaseset79inproliferationandcellstressresponse
AT barlevnickolaia roleoflysinemethyltransferaseset79inproliferationandcellstressresponse

Ejemplares similares