Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?

Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to provide the scientific and medical communities with innovative...

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Detalles Bibliográficos
Autores principales: Fréville, Aline, Gnangnon, Bénédicte, Khelifa, Asma S., Gissot, Mathieu, Khalife, Jamal, Pierrot, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949495/
https://www.ncbi.nlm.nih.gov/pubmed/35336160
http://dx.doi.org/10.3390/microorganisms10030585
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author Fréville, Aline
Gnangnon, Bénédicte
Khelifa, Asma S.
Gissot, Mathieu
Khalife, Jamal
Pierrot, Christine
author_facet Fréville, Aline
Gnangnon, Bénédicte
Khelifa, Asma S.
Gissot, Mathieu
Khalife, Jamal
Pierrot, Christine
author_sort Fréville, Aline
collection PubMed
description Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to provide the scientific and medical communities with innovative strategies specifically targeting these organisms. In this review, we present an overview of the diversity of the phosphatome as well as the variety of functions that phosphatases display throughout the Apicomplexan parasites’ life cycles. We also discuss how this diversity could be used for the design of innovative and specific new drugs/therapeutic strategies.
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spelling pubmed-89494952022-03-26 Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics? Fréville, Aline Gnangnon, Bénédicte Khelifa, Asma S. Gissot, Mathieu Khalife, Jamal Pierrot, Christine Microorganisms Review Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to provide the scientific and medical communities with innovative strategies specifically targeting these organisms. In this review, we present an overview of the diversity of the phosphatome as well as the variety of functions that phosphatases display throughout the Apicomplexan parasites’ life cycles. We also discuss how this diversity could be used for the design of innovative and specific new drugs/therapeutic strategies. MDPI 2022-03-08 /pmc/articles/PMC8949495/ /pubmed/35336160 http://dx.doi.org/10.3390/microorganisms10030585 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fréville, Aline
Gnangnon, Bénédicte
Khelifa, Asma S.
Gissot, Mathieu
Khalife, Jamal
Pierrot, Christine
Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?
title Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?
title_full Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?
title_fullStr Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?
title_full_unstemmed Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?
title_short Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?
title_sort deciphering the role of protein phosphatases in apicomplexa: the future of innovative therapeutics?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949495/
https://www.ncbi.nlm.nih.gov/pubmed/35336160
http://dx.doi.org/10.3390/microorganisms10030585
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