Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway

Cholangiocarcinoma (CCA) is an aggressive tumor of the biliary epithelium with poor survival that shows limited response to conventional chemotherapy. Increased expression of glucosylceramide synthase (GCS) contributes to drug resistance and the progression of various cancers; the expression profile...

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Detalles Bibliográficos
Autores principales: Chueakwon, Piyasiri, Jatooratthawichot, Peeranat, Talabnin, Krajang, Ketudat Cairns, James R., Talabnin, Chutima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949529/
https://www.ncbi.nlm.nih.gov/pubmed/35330102
http://dx.doi.org/10.3390/life12030351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949529/
https://www.ncbi.nlm.nih.gov/pubmed/35330102
http://dx.doi.org/10.3390/life12030351

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