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Physiologically Based Pharmacokinetic Modelling and Simulation to Predict the Plasma Concentration Profile of Doxorubicin

Doxorubicin (DOX) is still an important anticancer agent despite its tricky pharmacokinetics (PK) and toxicity potential. The advent of systems pharmacology enables the construction of PK models able to predict the concentration profiles of drugs and shed light on the underlying mechanisms involved...

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Detalles Bibliográficos
Autores principales:	Mystridis, George A., Batzias, Georgios C., Vizirianakis, Ioannis S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949582/ https://www.ncbi.nlm.nih.gov/pubmed/35335919 http://dx.doi.org/10.3390/pharmaceutics14030541

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