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The Role of Skin Immune System in Acne
Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949596/ https://www.ncbi.nlm.nih.gov/pubmed/35329904 http://dx.doi.org/10.3390/jcm11061579 |
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author | Firlej, Ewelina Kowalska, Wioleta Szymaszek, Karolina Roliński, Jacek Bartosińska, Joanna |
author_facet | Firlej, Ewelina Kowalska, Wioleta Szymaszek, Karolina Roliński, Jacek Bartosińska, Joanna |
author_sort | Firlej, Ewelina |
collection | PubMed |
description | Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes, which promotes inflammation. Little is known about the role of skin immune cells in the development of acne lesions. The aim of the study was to try to understand the role of skin immune cells in the course of acne. Recent studies have shown that there are at least four major pathways by which Cutibacterium acnes interacts with the innate immune system to induce inflammation: through TLRs, activating inflammasomes, inducing the production of matrix metalloproteinases (MMPs), and stimulating antimicrobial peptide (AMP) activity. Cells of adaptive immune response, mainly Th1 and Th17 lymphocytes, also play an important role in the pathogenesis of acne. It is worth emphasizing that understanding the role of the skin’s immune cells in the pathogenesis of acne may, in the future, contribute to the application of modern therapeutic strategies that would avoid addiction to antibiotics, which would alleviate the spectrum of resistance that is now evident and a current threat. |
format | Online Article Text |
id | pubmed-8949596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89495962022-03-26 The Role of Skin Immune System in Acne Firlej, Ewelina Kowalska, Wioleta Szymaszek, Karolina Roliński, Jacek Bartosińska, Joanna J Clin Med Review Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes, which promotes inflammation. Little is known about the role of skin immune cells in the development of acne lesions. The aim of the study was to try to understand the role of skin immune cells in the course of acne. Recent studies have shown that there are at least four major pathways by which Cutibacterium acnes interacts with the innate immune system to induce inflammation: through TLRs, activating inflammasomes, inducing the production of matrix metalloproteinases (MMPs), and stimulating antimicrobial peptide (AMP) activity. Cells of adaptive immune response, mainly Th1 and Th17 lymphocytes, also play an important role in the pathogenesis of acne. It is worth emphasizing that understanding the role of the skin’s immune cells in the pathogenesis of acne may, in the future, contribute to the application of modern therapeutic strategies that would avoid addiction to antibiotics, which would alleviate the spectrum of resistance that is now evident and a current threat. MDPI 2022-03-13 /pmc/articles/PMC8949596/ /pubmed/35329904 http://dx.doi.org/10.3390/jcm11061579 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Firlej, Ewelina Kowalska, Wioleta Szymaszek, Karolina Roliński, Jacek Bartosińska, Joanna The Role of Skin Immune System in Acne |
title | The Role of Skin Immune System in Acne |
title_full | The Role of Skin Immune System in Acne |
title_fullStr | The Role of Skin Immune System in Acne |
title_full_unstemmed | The Role of Skin Immune System in Acne |
title_short | The Role of Skin Immune System in Acne |
title_sort | role of skin immune system in acne |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949596/ https://www.ncbi.nlm.nih.gov/pubmed/35329904 http://dx.doi.org/10.3390/jcm11061579 |
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