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Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade

Pulcherrimin is a secondary metabolite of yeasts belonging to the Metschnikowia pulcherrima clade, and pulcherrimin formation is responsible for the antimicrobial action of its producers. Understanding the environmental function of this metabolite can provide insight into various microbial interacti...

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Detalles Bibliográficos
Autores principales: Kregiel, Dorota, Nowacka, Maria, Rygala, Anna, Vadkertiová, Renáta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949601/
https://www.ncbi.nlm.nih.gov/pubmed/35335219
http://dx.doi.org/10.3390/molecules27061855
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author Kregiel, Dorota
Nowacka, Maria
Rygala, Anna
Vadkertiová, Renáta
author_facet Kregiel, Dorota
Nowacka, Maria
Rygala, Anna
Vadkertiová, Renáta
author_sort Kregiel, Dorota
collection PubMed
description Pulcherrimin is a secondary metabolite of yeasts belonging to the Metschnikowia pulcherrima clade, and pulcherrimin formation is responsible for the antimicrobial action of its producers. Understanding the environmental function of this metabolite can provide insight into various microbial interactions and enables the efficient development of new effective bioproducts and methods. In this study, we evaluated the antimicrobial and antiadhesive action of yeast pulcherrimin, as well as its protective properties under selected stressful conditions. Classical microbiological plate methods, microscopy, and physico-chemical testing were used. The results show that pure pulcherrimin does not have antimicrobial properties, but its unique hydrophilic nature may hinder the adhesion of hydrophilic bacterial cells to abiotic surfaces. Pulcherrimin also proved to be a good cell protectant against UV–C radiation at both high and low temperatures.
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spelling pubmed-89496012022-03-26 Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade Kregiel, Dorota Nowacka, Maria Rygala, Anna Vadkertiová, Renáta Molecules Article Pulcherrimin is a secondary metabolite of yeasts belonging to the Metschnikowia pulcherrima clade, and pulcherrimin formation is responsible for the antimicrobial action of its producers. Understanding the environmental function of this metabolite can provide insight into various microbial interactions and enables the efficient development of new effective bioproducts and methods. In this study, we evaluated the antimicrobial and antiadhesive action of yeast pulcherrimin, as well as its protective properties under selected stressful conditions. Classical microbiological plate methods, microscopy, and physico-chemical testing were used. The results show that pure pulcherrimin does not have antimicrobial properties, but its unique hydrophilic nature may hinder the adhesion of hydrophilic bacterial cells to abiotic surfaces. Pulcherrimin also proved to be a good cell protectant against UV–C radiation at both high and low temperatures. MDPI 2022-03-12 /pmc/articles/PMC8949601/ /pubmed/35335219 http://dx.doi.org/10.3390/molecules27061855 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kregiel, Dorota
Nowacka, Maria
Rygala, Anna
Vadkertiová, Renáta
Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade
title Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade
title_full Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade
title_fullStr Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade
title_full_unstemmed Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade
title_short Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade
title_sort biological activity of pulcherrimin from the meschnikowia pulcherrima clade
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949601/
https://www.ncbi.nlm.nih.gov/pubmed/35335219
http://dx.doi.org/10.3390/molecules27061855
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