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HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks

Hepatocyte nuclear factor 1A (HNF1A) is the master regulator of liver homeostasis and organogenesis and regulates many aspects of hepatocyte functions. It acts as a tumor suppressor in the liver, evidenced by the increased proliferation in HNF1A knockout (KO) hepatocytes. Hence, we postulated that a...

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Detalles Bibliográficos
Autores principales:	Haque, Effi, Teeli, Aamir Salam, Winiarczyk, Dawid, Taguchi, Masahiko, Sakuraba, Shun, Kono, Hidetoshi, Leszczyński, Paweł, Pierzchała, Mariusz, Taniguchi, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949677/ https://www.ncbi.nlm.nih.gov/pubmed/35327967 http://dx.doi.org/10.3390/genes13030413

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