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Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study
BACKGROUND: Corneal collagen cross-linking (CXL) is considered an effective procedure for slowing down or eliminating the progression of keratoconus. New techniques, in combination with CXL, have been proposed to stop the evolution of keratoconus and improve the visual function. OBJECTIVE: To evalua...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949731/ https://www.ncbi.nlm.nih.gov/pubmed/35340750 http://dx.doi.org/10.1177/25158414221083362 |
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author | De Rosa, Giuseppe Rossi, Settimio Santamaria, Carmine Boccia, Rosa De Rosa, Luigi D’Alterio, Francesco Maria Simonelli, Francesca |
author_facet | De Rosa, Giuseppe Rossi, Settimio Santamaria, Carmine Boccia, Rosa De Rosa, Luigi D’Alterio, Francesco Maria Simonelli, Francesca |
author_sort | De Rosa, Giuseppe |
collection | PubMed |
description | BACKGROUND: Corneal collagen cross-linking (CXL) is considered an effective procedure for slowing down or eliminating the progression of keratoconus. New techniques, in combination with CXL, have been proposed to stop the evolution of keratoconus and improve the visual function. OBJECTIVE: To evaluate the effectiveness of combined photorefractive keratectomy (PRK) with mitomycin-C (MMC) application and CXL in the management of grade 1–2 keratoconus over a 2-year follow-up. METHODS: Fifteen eyes underwent topography-guided PRK with 0.02% MMC application immediately followed by standard CXL. RESULTS: Best corrected visual acuity improved from 0.15 ± 0.11 logMAR to 0.08 ± 0.09 logMAR at 24 months (p < 0.0001) in treated eyes. Mean steepest meridian keratometry reduced from 48.79 ± 3.22 D at baseline to 46.16 ± 3.11 D at 24 months (p < 0.0001). Mean flattest meridian keratometry reduced from 45.18 ± 2.17 D preoperatively to 44.35 ± 2.19 D at 24 months (p < 0.0001). CONCLUSION: Simultaneous topography-guided PRK with MMC 0.02% application and standard CXL is a safe, promising and effective procedure in the treatment of mild and moderate keratoconus. |
format | Online Article Text |
id | pubmed-8949731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-89497312022-03-26 Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study De Rosa, Giuseppe Rossi, Settimio Santamaria, Carmine Boccia, Rosa De Rosa, Luigi D’Alterio, Francesco Maria Simonelli, Francesca Ther Adv Ophthalmol Original Research BACKGROUND: Corneal collagen cross-linking (CXL) is considered an effective procedure for slowing down or eliminating the progression of keratoconus. New techniques, in combination with CXL, have been proposed to stop the evolution of keratoconus and improve the visual function. OBJECTIVE: To evaluate the effectiveness of combined photorefractive keratectomy (PRK) with mitomycin-C (MMC) application and CXL in the management of grade 1–2 keratoconus over a 2-year follow-up. METHODS: Fifteen eyes underwent topography-guided PRK with 0.02% MMC application immediately followed by standard CXL. RESULTS: Best corrected visual acuity improved from 0.15 ± 0.11 logMAR to 0.08 ± 0.09 logMAR at 24 months (p < 0.0001) in treated eyes. Mean steepest meridian keratometry reduced from 48.79 ± 3.22 D at baseline to 46.16 ± 3.11 D at 24 months (p < 0.0001). Mean flattest meridian keratometry reduced from 45.18 ± 2.17 D preoperatively to 44.35 ± 2.19 D at 24 months (p < 0.0001). CONCLUSION: Simultaneous topography-guided PRK with MMC 0.02% application and standard CXL is a safe, promising and effective procedure in the treatment of mild and moderate keratoconus. SAGE Publications 2022-03-23 /pmc/articles/PMC8949731/ /pubmed/35340750 http://dx.doi.org/10.1177/25158414221083362 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research De Rosa, Giuseppe Rossi, Settimio Santamaria, Carmine Boccia, Rosa De Rosa, Luigi D’Alterio, Francesco Maria Simonelli, Francesca Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study |
title | Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study |
title_full | Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study |
title_fullStr | Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study |
title_full_unstemmed | Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study |
title_short | Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study |
title_sort | combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949731/ https://www.ncbi.nlm.nih.gov/pubmed/35340750 http://dx.doi.org/10.1177/25158414221083362 |
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