Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1

In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete Amycolatopsis sp. WP1, yielded six novel amycolachromones A–F (1–6), together with five known analogues (7–11). Amycolachromones A–B (1–2) possessed unique dimer skeletons. The st...

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Detalles Bibliográficos
Autores principales: Chen, Jianwei, Chen, Jun, Wang, Siqi, Bao, Xiaoze, Li, Songwei, Wei, Bin, Zhang, Huawei, Wang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949813/
https://www.ncbi.nlm.nih.gov/pubmed/35323461
http://dx.doi.org/10.3390/md20030162
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author Chen, Jianwei
Chen, Jun
Wang, Siqi
Bao, Xiaoze
Li, Songwei
Wei, Bin
Zhang, Huawei
Wang, Hong
author_facet Chen, Jianwei
Chen, Jun
Wang, Siqi
Bao, Xiaoze
Li, Songwei
Wei, Bin
Zhang, Huawei
Wang, Hong
author_sort Chen, Jianwei
collection PubMed
description In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete Amycolatopsis sp. WP1, yielded six novel amycolachromones A–F (1–6), together with five known analogues (7–11). Amycolachromones A–B (1–2) possessed unique dimer skeletons. The structures and relative configurations of compounds 1–11 were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A–F were also proposed.
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spelling pubmed-89498132022-03-26 Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1 Chen, Jianwei Chen, Jun Wang, Siqi Bao, Xiaoze Li, Songwei Wei, Bin Zhang, Huawei Wang, Hong Mar Drugs Article In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete Amycolatopsis sp. WP1, yielded six novel amycolachromones A–F (1–6), together with five known analogues (7–11). Amycolachromones A–B (1–2) possessed unique dimer skeletons. The structures and relative configurations of compounds 1–11 were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A–F were also proposed. MDPI 2022-02-24 /pmc/articles/PMC8949813/ /pubmed/35323461 http://dx.doi.org/10.3390/md20030162 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Jianwei
Chen, Jun
Wang, Siqi
Bao, Xiaoze
Li, Songwei
Wei, Bin
Zhang, Huawei
Wang, Hong
Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1
title Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1
title_full Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1
title_fullStr Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1
title_full_unstemmed Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1
title_short Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1
title_sort amycolachromones a–f, isolated from a streptomycin-resistant strain of the deep-sea marine actinomycete amycolatopsis sp. wp1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949813/
https://www.ncbi.nlm.nih.gov/pubmed/35323461
http://dx.doi.org/10.3390/md20030162
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