Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Targeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagonists (or inverse agonists) shows promise to improve metabolic disorders associated with obesity. In this context, we designed and synthetized JM-00266, a new CB1R blocker with limited blood–brain barrier (BBB) permeability....

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Detalles Bibliográficos
Autores principales: Muller, Tania, Demizieux, Laurent, Troy-Fioramonti, Stéphanie, Buch, Chloé, Leemput, Julia, Belloir, Christine, Pais de Barros, Jean-Paul, Jourdan, Tony, Passilly-Degrace, Patricia, Fioramonti, Xavier, Le Bon, Anne-Marie, Vergès, Bruno, Robert, Jean-Michel, Degrace, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949893/
https://www.ncbi.nlm.nih.gov/pubmed/35328343
http://dx.doi.org/10.3390/ijms23062923

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