Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases

Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribut...

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Autores principales: Coppola, Serena, Avagliano, Carmen, Sacchi, Antonia, Laneri, Sonia, Calignano, Antonio, Voto, Luana, Luzzetti, Anna, Berni Canani, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949901/
https://www.ncbi.nlm.nih.gov/pubmed/35335213
http://dx.doi.org/10.3390/molecules27061849
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author Coppola, Serena
Avagliano, Carmen
Sacchi, Antonia
Laneri, Sonia
Calignano, Antonio
Voto, Luana
Luzzetti, Anna
Berni Canani, Roberto
author_facet Coppola, Serena
Avagliano, Carmen
Sacchi, Antonia
Laneri, Sonia
Calignano, Antonio
Voto, Luana
Luzzetti, Anna
Berni Canani, Roberto
author_sort Coppola, Serena
collection PubMed
description Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribute to the establishment of cutaneous homeostasis and can modulate host inflammatory responses. Imbalances in the SM structure and function (dysbiosis) are associated with several skin conditions. Therefore, novel target for the skincare field could be represented by strategies, which restore or preserve the SM natural/individual balance. Several of the beneficial effects exerted by the SM are aroused by the microbial metabolite butyrate. Since butyrate exerts a pivotal role in preserving skin health, it could be used as a postbiotic strategy for preventing or treating skin diseases. Herein, we describe and share perspectives of the potential clinical applications of therapeutic strategies using the postbiotic butyrate against human skin diseases.
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spelling pubmed-89499012022-03-26 Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases Coppola, Serena Avagliano, Carmen Sacchi, Antonia Laneri, Sonia Calignano, Antonio Voto, Luana Luzzetti, Anna Berni Canani, Roberto Molecules Review Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribute to the establishment of cutaneous homeostasis and can modulate host inflammatory responses. Imbalances in the SM structure and function (dysbiosis) are associated with several skin conditions. Therefore, novel target for the skincare field could be represented by strategies, which restore or preserve the SM natural/individual balance. Several of the beneficial effects exerted by the SM are aroused by the microbial metabolite butyrate. Since butyrate exerts a pivotal role in preserving skin health, it could be used as a postbiotic strategy for preventing or treating skin diseases. Herein, we describe and share perspectives of the potential clinical applications of therapeutic strategies using the postbiotic butyrate against human skin diseases. MDPI 2022-03-12 /pmc/articles/PMC8949901/ /pubmed/35335213 http://dx.doi.org/10.3390/molecules27061849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Coppola, Serena
Avagliano, Carmen
Sacchi, Antonia
Laneri, Sonia
Calignano, Antonio
Voto, Luana
Luzzetti, Anna
Berni Canani, Roberto
Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
title Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
title_full Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
title_fullStr Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
title_full_unstemmed Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
title_short Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
title_sort potential clinical applications of the postbiotic butyrate in human skin diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949901/
https://www.ncbi.nlm.nih.gov/pubmed/35335213
http://dx.doi.org/10.3390/molecules27061849
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