Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribut...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949901/ https://www.ncbi.nlm.nih.gov/pubmed/35335213 http://dx.doi.org/10.3390/molecules27061849 |
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author | Coppola, Serena Avagliano, Carmen Sacchi, Antonia Laneri, Sonia Calignano, Antonio Voto, Luana Luzzetti, Anna Berni Canani, Roberto |
author_facet | Coppola, Serena Avagliano, Carmen Sacchi, Antonia Laneri, Sonia Calignano, Antonio Voto, Luana Luzzetti, Anna Berni Canani, Roberto |
author_sort | Coppola, Serena |
collection | PubMed |
description | Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribute to the establishment of cutaneous homeostasis and can modulate host inflammatory responses. Imbalances in the SM structure and function (dysbiosis) are associated with several skin conditions. Therefore, novel target for the skincare field could be represented by strategies, which restore or preserve the SM natural/individual balance. Several of the beneficial effects exerted by the SM are aroused by the microbial metabolite butyrate. Since butyrate exerts a pivotal role in preserving skin health, it could be used as a postbiotic strategy for preventing or treating skin diseases. Herein, we describe and share perspectives of the potential clinical applications of therapeutic strategies using the postbiotic butyrate against human skin diseases. |
format | Online Article Text |
id | pubmed-8949901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89499012022-03-26 Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases Coppola, Serena Avagliano, Carmen Sacchi, Antonia Laneri, Sonia Calignano, Antonio Voto, Luana Luzzetti, Anna Berni Canani, Roberto Molecules Review Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribute to the establishment of cutaneous homeostasis and can modulate host inflammatory responses. Imbalances in the SM structure and function (dysbiosis) are associated with several skin conditions. Therefore, novel target for the skincare field could be represented by strategies, which restore or preserve the SM natural/individual balance. Several of the beneficial effects exerted by the SM are aroused by the microbial metabolite butyrate. Since butyrate exerts a pivotal role in preserving skin health, it could be used as a postbiotic strategy for preventing or treating skin diseases. Herein, we describe and share perspectives of the potential clinical applications of therapeutic strategies using the postbiotic butyrate against human skin diseases. MDPI 2022-03-12 /pmc/articles/PMC8949901/ /pubmed/35335213 http://dx.doi.org/10.3390/molecules27061849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Coppola, Serena Avagliano, Carmen Sacchi, Antonia Laneri, Sonia Calignano, Antonio Voto, Luana Luzzetti, Anna Berni Canani, Roberto Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases |
title | Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases |
title_full | Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases |
title_fullStr | Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases |
title_full_unstemmed | Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases |
title_short | Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases |
title_sort | potential clinical applications of the postbiotic butyrate in human skin diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949901/ https://www.ncbi.nlm.nih.gov/pubmed/35335213 http://dx.doi.org/10.3390/molecules27061849 |
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