Cargando…
Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys
Although undisputed for its anti-inflammatory and immune system boosting properties, vitamin C remains an inconsistently investigated nutrient in the United States. However, subclinical inadequacies may partly explain increased inflammation and decreased immune function within the population. This s...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950002/ https://www.ncbi.nlm.nih.gov/pubmed/35334908 http://dx.doi.org/10.3390/nu14061254 |
_version_ | 1784675038966841344 |
---|---|
author | Crook, Jennifer Marie Horgas, Ann L. Yoon, Saunjoo L. Grundmann, Oliver Johnson-Mallard, Versie |
author_facet | Crook, Jennifer Marie Horgas, Ann L. Yoon, Saunjoo L. Grundmann, Oliver Johnson-Mallard, Versie |
author_sort | Crook, Jennifer Marie |
collection | PubMed |
description | Although undisputed for its anti-inflammatory and immune system boosting properties, vitamin C remains an inconsistently investigated nutrient in the United States. However, subclinical inadequacies may partly explain increased inflammation and decreased immune function within the population. This secondary analysis cross-sectional study used the 2003–2006 NHANES surveys to identify more clearly the association between plasma vitamin C and clinical biomarkers of acute and chronic inflammation C-reactive protein (CRP) and red cell distribution width (RDW). From plasma vitamin C levels separated into five defined categories (deficiency, hypovitaminosis, inadequate, adequate, and saturating), ANOVA tests identified significant differences in means in all insufficient vitamin C categories (deficiency, hypovitaminosis, and inadequate) and both CRP and RDW in 7607 study participants. There were also statistically significant differences in means between sufficient plasma vitamin C levels (adequate and saturating categories) and CRP. Significant differences were not identified between adequate and saturating plasma vitamin C levels and RDW. Although inadequate levels of vitamin C may not exhibit overt signs or symptoms of deficiency, differences in mean levels identified between inflammatory biomarkers suggest a closer examination of those considered at risk for inflammatory-driven diseases. Likewise, the subclinical levels of inflammation presented in this study provide evidence to support ranges for further clinical inflammation surveillance. |
format | Online Article Text |
id | pubmed-8950002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89500022022-03-26 Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys Crook, Jennifer Marie Horgas, Ann L. Yoon, Saunjoo L. Grundmann, Oliver Johnson-Mallard, Versie Nutrients Article Although undisputed for its anti-inflammatory and immune system boosting properties, vitamin C remains an inconsistently investigated nutrient in the United States. However, subclinical inadequacies may partly explain increased inflammation and decreased immune function within the population. This secondary analysis cross-sectional study used the 2003–2006 NHANES surveys to identify more clearly the association between plasma vitamin C and clinical biomarkers of acute and chronic inflammation C-reactive protein (CRP) and red cell distribution width (RDW). From plasma vitamin C levels separated into five defined categories (deficiency, hypovitaminosis, inadequate, adequate, and saturating), ANOVA tests identified significant differences in means in all insufficient vitamin C categories (deficiency, hypovitaminosis, and inadequate) and both CRP and RDW in 7607 study participants. There were also statistically significant differences in means between sufficient plasma vitamin C levels (adequate and saturating categories) and CRP. Significant differences were not identified between adequate and saturating plasma vitamin C levels and RDW. Although inadequate levels of vitamin C may not exhibit overt signs or symptoms of deficiency, differences in mean levels identified between inflammatory biomarkers suggest a closer examination of those considered at risk for inflammatory-driven diseases. Likewise, the subclinical levels of inflammation presented in this study provide evidence to support ranges for further clinical inflammation surveillance. MDPI 2022-03-16 /pmc/articles/PMC8950002/ /pubmed/35334908 http://dx.doi.org/10.3390/nu14061254 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Crook, Jennifer Marie Horgas, Ann L. Yoon, Saunjoo L. Grundmann, Oliver Johnson-Mallard, Versie Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys |
title | Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys |
title_full | Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys |
title_fullStr | Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys |
title_full_unstemmed | Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys |
title_short | Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003–2006 Surveys |
title_sort | vitamin c plasma levels associated with inflammatory biomarkers, crp and rdw: results from the nhanes 2003–2006 surveys |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950002/ https://www.ncbi.nlm.nih.gov/pubmed/35334908 http://dx.doi.org/10.3390/nu14061254 |
work_keys_str_mv | AT crookjennifermarie vitamincplasmalevelsassociatedwithinflammatorybiomarkerscrpandrdwresultsfromthenhanes20032006surveys AT horgasannl vitamincplasmalevelsassociatedwithinflammatorybiomarkerscrpandrdwresultsfromthenhanes20032006surveys AT yoonsaunjool vitamincplasmalevelsassociatedwithinflammatorybiomarkerscrpandrdwresultsfromthenhanes20032006surveys AT grundmannoliver vitamincplasmalevelsassociatedwithinflammatorybiomarkerscrpandrdwresultsfromthenhanes20032006surveys AT johnsonmallardversie vitamincplasmalevelsassociatedwithinflammatorybiomarkerscrpandrdwresultsfromthenhanes20032006surveys |