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An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape
3D facial surface imaging is a useful tool in dentistry and in terms of diagnostics and treatment planning. Between-group PCA (bgPCA) is a method that has been used to analyse shapes in biological morphometrics, although various “pathologies” of bgPCA have recently been proposed. Monte Carlo (MC) si...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950128/ https://www.ncbi.nlm.nih.gov/pubmed/35324618 http://dx.doi.org/10.3390/jimaging8030063 |
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author | Farnell, Damian J. J. |
author_facet | Farnell, Damian J. J. |
author_sort | Farnell, Damian J. J. |
collection | PubMed |
description | 3D facial surface imaging is a useful tool in dentistry and in terms of diagnostics and treatment planning. Between-group PCA (bgPCA) is a method that has been used to analyse shapes in biological morphometrics, although various “pathologies” of bgPCA have recently been proposed. Monte Carlo (MC) simulated datasets were created here in order to explore “pathologies” of multilevel PCA (mPCA), where mPCA with two levels is equivalent to bgPCA. The first set of MC experiments involved 300 uncorrelated normally distributed variables, whereas the second set of MC experiments used correlated multivariate MC data describing 3D facial shape. We confirmed results of numerical experiments from other researchers that indicated that bgPCA (and so also mPCA) can give a false impression of strong differences in component scores between groups when there is none in reality. These spurious differences in component scores via mPCA decreased significantly as the sample sizes per group were increased. Eigenvalues via mPCA were also found to be strongly affected by imbalances in sample sizes per group, although this problem was removed by using weighted forms of covariance matrices suggested by the maximum likelihood solution of the two-level model. However, this did not solve problems of spurious differences between groups in these simulations, which was driven by very small sample sizes in one group. As a “rule of thumb” only, all of our experiments indicate that reasonable results are obtained when sample sizes per group in all groups are at least equal to the number of variables. Interestingly, the sum of all eigenvalues over both levels via mPCA scaled approximately linearly with the inverse of the sample size per group in all experiments. Finally, between-group variation was added explicitly to the MC data generation model in two experiments considered here. Results for the sum of all eigenvalues via mPCA predicted the asymptotic amount for the total amount of variance correctly in this case, whereas standard “single-level” PCA underestimated this quantity. |
format | Online Article Text |
id | pubmed-8950128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89501282022-03-26 An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape Farnell, Damian J. J. J Imaging Article 3D facial surface imaging is a useful tool in dentistry and in terms of diagnostics and treatment planning. Between-group PCA (bgPCA) is a method that has been used to analyse shapes in biological morphometrics, although various “pathologies” of bgPCA have recently been proposed. Monte Carlo (MC) simulated datasets were created here in order to explore “pathologies” of multilevel PCA (mPCA), where mPCA with two levels is equivalent to bgPCA. The first set of MC experiments involved 300 uncorrelated normally distributed variables, whereas the second set of MC experiments used correlated multivariate MC data describing 3D facial shape. We confirmed results of numerical experiments from other researchers that indicated that bgPCA (and so also mPCA) can give a false impression of strong differences in component scores between groups when there is none in reality. These spurious differences in component scores via mPCA decreased significantly as the sample sizes per group were increased. Eigenvalues via mPCA were also found to be strongly affected by imbalances in sample sizes per group, although this problem was removed by using weighted forms of covariance matrices suggested by the maximum likelihood solution of the two-level model. However, this did not solve problems of spurious differences between groups in these simulations, which was driven by very small sample sizes in one group. As a “rule of thumb” only, all of our experiments indicate that reasonable results are obtained when sample sizes per group in all groups are at least equal to the number of variables. Interestingly, the sum of all eigenvalues over both levels via mPCA scaled approximately linearly with the inverse of the sample size per group in all experiments. Finally, between-group variation was added explicitly to the MC data generation model in two experiments considered here. Results for the sum of all eigenvalues via mPCA predicted the asymptotic amount for the total amount of variance correctly in this case, whereas standard “single-level” PCA underestimated this quantity. MDPI 2022-03-04 /pmc/articles/PMC8950128/ /pubmed/35324618 http://dx.doi.org/10.3390/jimaging8030063 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Farnell, Damian J. J. An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape |
title | An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape |
title_full | An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape |
title_fullStr | An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape |
title_full_unstemmed | An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape |
title_short | An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape |
title_sort | exploration of pathologies of multilevel principal components analysis in statistical models of shape |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950128/ https://www.ncbi.nlm.nih.gov/pubmed/35324618 http://dx.doi.org/10.3390/jimaging8030063 |
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