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Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event

In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festiv...

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Autores principales: Bertram, Ralph, Bartsch, Vanessa, Sodmann, Johanna, Hennig, Luca, Müjde, Engin, Stock, Jonathan, Ruedig, Vivienne, Sodmann, Philipp, Todt, Daniel, Steinmann, Eike, Hitzl, Wolfgang, Steinmann, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950301/
https://www.ncbi.nlm.nih.gov/pubmed/35335064
http://dx.doi.org/10.3390/vaccines10030432
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author Bertram, Ralph
Bartsch, Vanessa
Sodmann, Johanna
Hennig, Luca
Müjde, Engin
Stock, Jonathan
Ruedig, Vivienne
Sodmann, Philipp
Todt, Daniel
Steinmann, Eike
Hitzl, Wolfgang
Steinmann, Joerg
author_facet Bertram, Ralph
Bartsch, Vanessa
Sodmann, Johanna
Hennig, Luca
Müjde, Engin
Stock, Jonathan
Ruedig, Vivienne
Sodmann, Philipp
Todt, Daniel
Steinmann, Eike
Hitzl, Wolfgang
Steinmann, Joerg
author_sort Bertram, Ralph
collection PubMed
description In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants’ vaccination status.
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spelling pubmed-89503012022-03-26 Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event Bertram, Ralph Bartsch, Vanessa Sodmann, Johanna Hennig, Luca Müjde, Engin Stock, Jonathan Ruedig, Vivienne Sodmann, Philipp Todt, Daniel Steinmann, Eike Hitzl, Wolfgang Steinmann, Joerg Vaccines (Basel) Article In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants’ vaccination status. MDPI 2022-03-11 /pmc/articles/PMC8950301/ /pubmed/35335064 http://dx.doi.org/10.3390/vaccines10030432 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bertram, Ralph
Bartsch, Vanessa
Sodmann, Johanna
Hennig, Luca
Müjde, Engin
Stock, Jonathan
Ruedig, Vivienne
Sodmann, Philipp
Todt, Daniel
Steinmann, Eike
Hitzl, Wolfgang
Steinmann, Joerg
Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event
title Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event
title_full Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event
title_fullStr Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event
title_full_unstemmed Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event
title_short Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event
title_sort risk stratification of sars-cov-2 breakthrough infections based on an outbreak at a student festive event
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950301/
https://www.ncbi.nlm.nih.gov/pubmed/35335064
http://dx.doi.org/10.3390/vaccines10030432
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