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Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event
In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festiv...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950301/ https://www.ncbi.nlm.nih.gov/pubmed/35335064 http://dx.doi.org/10.3390/vaccines10030432 |
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author | Bertram, Ralph Bartsch, Vanessa Sodmann, Johanna Hennig, Luca Müjde, Engin Stock, Jonathan Ruedig, Vivienne Sodmann, Philipp Todt, Daniel Steinmann, Eike Hitzl, Wolfgang Steinmann, Joerg |
author_facet | Bertram, Ralph Bartsch, Vanessa Sodmann, Johanna Hennig, Luca Müjde, Engin Stock, Jonathan Ruedig, Vivienne Sodmann, Philipp Todt, Daniel Steinmann, Eike Hitzl, Wolfgang Steinmann, Joerg |
author_sort | Bertram, Ralph |
collection | PubMed |
description | In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants’ vaccination status. |
format | Online Article Text |
id | pubmed-8950301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89503012022-03-26 Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event Bertram, Ralph Bartsch, Vanessa Sodmann, Johanna Hennig, Luca Müjde, Engin Stock, Jonathan Ruedig, Vivienne Sodmann, Philipp Todt, Daniel Steinmann, Eike Hitzl, Wolfgang Steinmann, Joerg Vaccines (Basel) Article In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants’ vaccination status. MDPI 2022-03-11 /pmc/articles/PMC8950301/ /pubmed/35335064 http://dx.doi.org/10.3390/vaccines10030432 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bertram, Ralph Bartsch, Vanessa Sodmann, Johanna Hennig, Luca Müjde, Engin Stock, Jonathan Ruedig, Vivienne Sodmann, Philipp Todt, Daniel Steinmann, Eike Hitzl, Wolfgang Steinmann, Joerg Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event |
title | Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event |
title_full | Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event |
title_fullStr | Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event |
title_full_unstemmed | Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event |
title_short | Risk Stratification of SARS-CoV-2 Breakthrough Infections Based on an Outbreak at a Student Festive Event |
title_sort | risk stratification of sars-cov-2 breakthrough infections based on an outbreak at a student festive event |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950301/ https://www.ncbi.nlm.nih.gov/pubmed/35335064 http://dx.doi.org/10.3390/vaccines10030432 |
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