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Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study

Introduction: Certain metabolic parameters increase the risk of esophageal cancer. This study investigated the association between the variability in metabolic parameters and esophageal cancer incidence using large nationally representative data. Methods: Using the health checkup and claims data pro...

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Autores principales: Lee, Ji Eun, Han, Kyungdo, Yoo, Juhwan, Yeo, Yohwan, Cho, In Young, Cho, Belong, Kwon, Hyuktae, Shin, Dong Wook, Cho, Jong Ho, Park, Yong-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950346/
https://www.ncbi.nlm.nih.gov/pubmed/35330375
http://dx.doi.org/10.3390/jpm12030375
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author Lee, Ji Eun
Han, Kyungdo
Yoo, Juhwan
Yeo, Yohwan
Cho, In Young
Cho, Belong
Kwon, Hyuktae
Shin, Dong Wook
Cho, Jong Ho
Park, Yong-Moon
author_facet Lee, Ji Eun
Han, Kyungdo
Yoo, Juhwan
Yeo, Yohwan
Cho, In Young
Cho, Belong
Kwon, Hyuktae
Shin, Dong Wook
Cho, Jong Ho
Park, Yong-Moon
author_sort Lee, Ji Eun
collection PubMed
description Introduction: Certain metabolic parameters increase the risk of esophageal cancer. This study investigated the association between the variability in metabolic parameters and esophageal cancer incidence using large nationally representative data. Methods: Using the health checkup and claims data provided by the Korean National Health Insurance Service (NHIS), we included 8,376,233 subjects who underwent NHIS-provided health checkups between 2009 and 2010 (index year) and two or more health checkups within five years before the index year. Hazard ratios (HRs) and 95% confidence intervals (CIs) for esophageal cancer were obtained using Cox proportional hazards models according to the quartiles of variability of each metabolic parameter: fasting blood glucose (FBG), weight, systolic blood pressure (SBP), and total cholesterol (TC) as well as a cumulative number of high-variability parameters. Results: A total of 6,455 cases of esophageal cancer occurred during a mean (±SD) follow-up of 8.8 (±1.1) years. The following metabolic parameters were used, with an adjusted HR and 95% CI: FBG (1.11, 1.03–1.18), weight (1.15, 1.07–1.23), SBP (1.08, 1.01–1.16), and TC (1.23, 1.15–1.32). The risk of esophageal cancer was higher in the highest quartile of variability than the lower quartiles. The risk of esophageal cancer gradually increased with a greater number of high-variability parameters: 1.08 (1.02–1.15), 1.22 (1.14–1.31), and 1.33 (1.21–1.46) for 1, 2, and 3–4 high-variability parameters (vs. none). Conclusions: A high variability of metabolic parameters was associated with an increased esophageal cancer risk. Further studies are needed to replicate our findings in other populations.
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spelling pubmed-89503462022-03-26 Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study Lee, Ji Eun Han, Kyungdo Yoo, Juhwan Yeo, Yohwan Cho, In Young Cho, Belong Kwon, Hyuktae Shin, Dong Wook Cho, Jong Ho Park, Yong-Moon J Pers Med Article Introduction: Certain metabolic parameters increase the risk of esophageal cancer. This study investigated the association between the variability in metabolic parameters and esophageal cancer incidence using large nationally representative data. Methods: Using the health checkup and claims data provided by the Korean National Health Insurance Service (NHIS), we included 8,376,233 subjects who underwent NHIS-provided health checkups between 2009 and 2010 (index year) and two or more health checkups within five years before the index year. Hazard ratios (HRs) and 95% confidence intervals (CIs) for esophageal cancer were obtained using Cox proportional hazards models according to the quartiles of variability of each metabolic parameter: fasting blood glucose (FBG), weight, systolic blood pressure (SBP), and total cholesterol (TC) as well as a cumulative number of high-variability parameters. Results: A total of 6,455 cases of esophageal cancer occurred during a mean (±SD) follow-up of 8.8 (±1.1) years. The following metabolic parameters were used, with an adjusted HR and 95% CI: FBG (1.11, 1.03–1.18), weight (1.15, 1.07–1.23), SBP (1.08, 1.01–1.16), and TC (1.23, 1.15–1.32). The risk of esophageal cancer was higher in the highest quartile of variability than the lower quartiles. The risk of esophageal cancer gradually increased with a greater number of high-variability parameters: 1.08 (1.02–1.15), 1.22 (1.14–1.31), and 1.33 (1.21–1.46) for 1, 2, and 3–4 high-variability parameters (vs. none). Conclusions: A high variability of metabolic parameters was associated with an increased esophageal cancer risk. Further studies are needed to replicate our findings in other populations. MDPI 2022-03-01 /pmc/articles/PMC8950346/ /pubmed/35330375 http://dx.doi.org/10.3390/jpm12030375 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Ji Eun
Han, Kyungdo
Yoo, Juhwan
Yeo, Yohwan
Cho, In Young
Cho, Belong
Kwon, Hyuktae
Shin, Dong Wook
Cho, Jong Ho
Park, Yong-Moon
Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study
title Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study
title_full Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study
title_fullStr Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study
title_full_unstemmed Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study
title_short Association of Metabolic Parameter Variability with Esophageal Cancer Risk: A Nationwide Population-Based Study
title_sort association of metabolic parameter variability with esophageal cancer risk: a nationwide population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950346/
https://www.ncbi.nlm.nih.gov/pubmed/35330375
http://dx.doi.org/10.3390/jpm12030375
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