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Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19

A 48-year-old female patient underwent a heart transplantation for acute fulminant myocarditis, following heterologous vaccination with the ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19. She had no history of severe acute respiratory syndrome coronavirus-2 infection. She did not exhibit clinical sign...

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Autores principales: Kang, Dong-Hoon, Na, Joo-Young, Yang, Jun-Ho, Moon, Seong-Ho, Kim, Sung-Hwan, Jung, Jae-Jun, Cha, Ho-Jeong, Ahn, Jong-Hwa, Park, Yong-Whi, Cho, Sang-Yeong, Yu, Ho-Kyung, Lee, Soo-Hee, Park, Mi-Yeong, Kim, Jong-Woo, Byun, Joung-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950462/
https://www.ncbi.nlm.nih.gov/pubmed/35334625
http://dx.doi.org/10.3390/medicina58030449
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author Kang, Dong-Hoon
Na, Joo-Young
Yang, Jun-Ho
Moon, Seong-Ho
Kim, Sung-Hwan
Jung, Jae-Jun
Cha, Ho-Jeong
Ahn, Jong-Hwa
Park, Yong-Whi
Cho, Sang-Yeong
Yu, Ho-Kyung
Lee, Soo-Hee
Park, Mi-Yeong
Kim, Jong-Woo
Byun, Joung-Hun
author_facet Kang, Dong-Hoon
Na, Joo-Young
Yang, Jun-Ho
Moon, Seong-Ho
Kim, Sung-Hwan
Jung, Jae-Jun
Cha, Ho-Jeong
Ahn, Jong-Hwa
Park, Yong-Whi
Cho, Sang-Yeong
Yu, Ho-Kyung
Lee, Soo-Hee
Park, Mi-Yeong
Kim, Jong-Woo
Byun, Joung-Hun
author_sort Kang, Dong-Hoon
collection PubMed
description A 48-year-old female patient underwent a heart transplantation for acute fulminant myocarditis, following heterologous vaccination with the ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19. She had no history of severe acute respiratory syndrome coronavirus-2 infection. She did not exhibit clinical signs or have laboratory findings of concomitant infection before or after vaccination. Heart transplantation was performed because her heart failed to recover with venoarterial extracorporeal oxygenation support. Organ autopsy revealed giant cell myocarditis, possibly related to the vaccines. Clinicians may have to consider the possibility of the development of giant cell myocarditis, especially in patients with rapidly deteriorating cardiac function and myocarditis symptoms after COVID-19 vaccination.
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spelling pubmed-89504622022-03-26 Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19 Kang, Dong-Hoon Na, Joo-Young Yang, Jun-Ho Moon, Seong-Ho Kim, Sung-Hwan Jung, Jae-Jun Cha, Ho-Jeong Ahn, Jong-Hwa Park, Yong-Whi Cho, Sang-Yeong Yu, Ho-Kyung Lee, Soo-Hee Park, Mi-Yeong Kim, Jong-Woo Byun, Joung-Hun Medicina (Kaunas) Case Report A 48-year-old female patient underwent a heart transplantation for acute fulminant myocarditis, following heterologous vaccination with the ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19. She had no history of severe acute respiratory syndrome coronavirus-2 infection. She did not exhibit clinical signs or have laboratory findings of concomitant infection before or after vaccination. Heart transplantation was performed because her heart failed to recover with venoarterial extracorporeal oxygenation support. Organ autopsy revealed giant cell myocarditis, possibly related to the vaccines. Clinicians may have to consider the possibility of the development of giant cell myocarditis, especially in patients with rapidly deteriorating cardiac function and myocarditis symptoms after COVID-19 vaccination. MDPI 2022-03-20 /pmc/articles/PMC8950462/ /pubmed/35334625 http://dx.doi.org/10.3390/medicina58030449 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kang, Dong-Hoon
Na, Joo-Young
Yang, Jun-Ho
Moon, Seong-Ho
Kim, Sung-Hwan
Jung, Jae-Jun
Cha, Ho-Jeong
Ahn, Jong-Hwa
Park, Yong-Whi
Cho, Sang-Yeong
Yu, Ho-Kyung
Lee, Soo-Hee
Park, Mi-Yeong
Kim, Jong-Woo
Byun, Joung-Hun
Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19
title Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19
title_full Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19
title_fullStr Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19
title_full_unstemmed Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19
title_short Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19
title_sort fulminant giant cell myocarditis following heterologous vaccination of chadox1 ncov-19 and pfizer-biontech covid-19
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950462/
https://www.ncbi.nlm.nih.gov/pubmed/35334625
http://dx.doi.org/10.3390/medicina58030449
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