Characterization of PCLO Gene in Amazonian Native American Populations

Genetic variations in PCLO have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We i...

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Autores principales: Cohen-Paes, Amanda de Nazaré, de Carvalho, Darlen Cardoso, Pastana, Lucas Favacho, Dobbin, Elizabeth Ayres Fragoso, Moreira, Fabiano Cordeiro, de Souza, Tatiane Piedade, Fernandes, Marianne Rodrigues, Leal, Diana Feio da Veiga Borges, de Sá, Roberta Borges Andrade, de Alcântara, Angélica Leite, Guerreiro, João Farias, Ribeiro-dos-Santos, Ândrea, dos Santos, Sidney Emanuel Batista, de Assumpção, Paulo Pimentel, dos Santos, Ney Pereira Carneiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950494/
https://www.ncbi.nlm.nih.gov/pubmed/35328053
http://dx.doi.org/10.3390/genes13030499
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author Cohen-Paes, Amanda de Nazaré
de Carvalho, Darlen Cardoso
Pastana, Lucas Favacho
Dobbin, Elizabeth Ayres Fragoso
Moreira, Fabiano Cordeiro
de Souza, Tatiane Piedade
Fernandes, Marianne Rodrigues
Leal, Diana Feio da Veiga Borges
de Sá, Roberta Borges Andrade
de Alcântara, Angélica Leite
Guerreiro, João Farias
Ribeiro-dos-Santos, Ândrea
dos Santos, Sidney Emanuel Batista
de Assumpção, Paulo Pimentel
dos Santos, Ney Pereira Carneiro
author_facet Cohen-Paes, Amanda de Nazaré
de Carvalho, Darlen Cardoso
Pastana, Lucas Favacho
Dobbin, Elizabeth Ayres Fragoso
Moreira, Fabiano Cordeiro
de Souza, Tatiane Piedade
Fernandes, Marianne Rodrigues
Leal, Diana Feio da Veiga Borges
de Sá, Roberta Borges Andrade
de Alcântara, Angélica Leite
Guerreiro, João Farias
Ribeiro-dos-Santos, Ândrea
dos Santos, Sidney Emanuel Batista
de Assumpção, Paulo Pimentel
dos Santos, Ney Pereira Carneiro
author_sort Cohen-Paes, Amanda de Nazaré
collection PubMed
description Genetic variations in PCLO have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We investigated 18 genetic variants in the PCLO gene in Amazonian indigenous and compared our results with the ones found in global populations, which were publicly available in the 1000 Genomes Project, gnmAD and ABraOM databases. The results demonstrated that the variants of the PCLO, especially rs17156844, rs550369696, rs61741659 and rs2877, have a significantly higher frequency in Amerindian populations in comparison with other continental populations. These data outline the singular genetic profile of the Native American population from the Brazilian Amazon region.
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spelling pubmed-89504942022-03-26 Characterization of PCLO Gene in Amazonian Native American Populations Cohen-Paes, Amanda de Nazaré de Carvalho, Darlen Cardoso Pastana, Lucas Favacho Dobbin, Elizabeth Ayres Fragoso Moreira, Fabiano Cordeiro de Souza, Tatiane Piedade Fernandes, Marianne Rodrigues Leal, Diana Feio da Veiga Borges de Sá, Roberta Borges Andrade de Alcântara, Angélica Leite Guerreiro, João Farias Ribeiro-dos-Santos, Ândrea dos Santos, Sidney Emanuel Batista de Assumpção, Paulo Pimentel dos Santos, Ney Pereira Carneiro Genes (Basel) Article Genetic variations in PCLO have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We investigated 18 genetic variants in the PCLO gene in Amazonian indigenous and compared our results with the ones found in global populations, which were publicly available in the 1000 Genomes Project, gnmAD and ABraOM databases. The results demonstrated that the variants of the PCLO, especially rs17156844, rs550369696, rs61741659 and rs2877, have a significantly higher frequency in Amerindian populations in comparison with other continental populations. These data outline the singular genetic profile of the Native American population from the Brazilian Amazon region. MDPI 2022-03-11 /pmc/articles/PMC8950494/ /pubmed/35328053 http://dx.doi.org/10.3390/genes13030499 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cohen-Paes, Amanda de Nazaré
de Carvalho, Darlen Cardoso
Pastana, Lucas Favacho
Dobbin, Elizabeth Ayres Fragoso
Moreira, Fabiano Cordeiro
de Souza, Tatiane Piedade
Fernandes, Marianne Rodrigues
Leal, Diana Feio da Veiga Borges
de Sá, Roberta Borges Andrade
de Alcântara, Angélica Leite
Guerreiro, João Farias
Ribeiro-dos-Santos, Ândrea
dos Santos, Sidney Emanuel Batista
de Assumpção, Paulo Pimentel
dos Santos, Ney Pereira Carneiro
Characterization of PCLO Gene in Amazonian Native American Populations
title Characterization of PCLO Gene in Amazonian Native American Populations
title_full Characterization of PCLO Gene in Amazonian Native American Populations
title_fullStr Characterization of PCLO Gene in Amazonian Native American Populations
title_full_unstemmed Characterization of PCLO Gene in Amazonian Native American Populations
title_short Characterization of PCLO Gene in Amazonian Native American Populations
title_sort characterization of pclo gene in amazonian native american populations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950494/
https://www.ncbi.nlm.nih.gov/pubmed/35328053
http://dx.doi.org/10.3390/genes13030499
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