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Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview

The epicardium is the outermost cell layer in the vertebrate heart that originates during development from mesothelial precursors located in the proepicardium and septum transversum. The epicardial layer plays a key role during cardiogenesis since a subset of epicardial-derived cells (EPDCs) undergo...

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Autores principales: Sanchez-Fernandez, Cristina, Rodriguez-Outeiriño, Lara, Matias-Valiente, Lidia, Ramirez de Acuña, Felicitas, Hernandez-Torres, Francisco, Lozano-Velasco, Estefania, Dominguez, Jorge N., Franco, Diego, Aranega, Amelia Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950551/
https://www.ncbi.nlm.nih.gov/pubmed/35328640
http://dx.doi.org/10.3390/ijms23063220
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author Sanchez-Fernandez, Cristina
Rodriguez-Outeiriño, Lara
Matias-Valiente, Lidia
Ramirez de Acuña, Felicitas
Hernandez-Torres, Francisco
Lozano-Velasco, Estefania
Dominguez, Jorge N.
Franco, Diego
Aranega, Amelia Eva
author_facet Sanchez-Fernandez, Cristina
Rodriguez-Outeiriño, Lara
Matias-Valiente, Lidia
Ramirez de Acuña, Felicitas
Hernandez-Torres, Francisco
Lozano-Velasco, Estefania
Dominguez, Jorge N.
Franco, Diego
Aranega, Amelia Eva
author_sort Sanchez-Fernandez, Cristina
collection PubMed
description The epicardium is the outermost cell layer in the vertebrate heart that originates during development from mesothelial precursors located in the proepicardium and septum transversum. The epicardial layer plays a key role during cardiogenesis since a subset of epicardial-derived cells (EPDCs) undergo an epithelial–mesenchymal transition (EMT); migrate into the myocardium; and differentiate into distinct cell types, such as coronary vascular smooth muscle cells, cardiac fibroblasts, endothelial cells, and presumably a subpopulation of cardiomyocytes, thus contributing to complete heart formation. Furthermore, the epicardium is a source of paracrine factors that support cardiac growth at the last stages of cardiogenesis. Although several lineage trace studies have provided some evidence about epicardial cell fate determination, the molecular mechanisms underlying epicardial cell heterogeneity remain not fully understood. Interestingly, seminal works during the last decade have pointed out that the adult epicardium is reactivated after heart damage, re-expressing some embryonic genes and contributing to cardiac remodeling. Therefore, the epicardium has been proposed as a potential target in the treatment of cardiovascular disease. In this review, we summarize the previous knowledge regarding the regulation of epicardial cell contribution during development and the control of epicardial reactivation in cardiac repair after damage.
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spelling pubmed-89505512022-03-26 Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview Sanchez-Fernandez, Cristina Rodriguez-Outeiriño, Lara Matias-Valiente, Lidia Ramirez de Acuña, Felicitas Hernandez-Torres, Francisco Lozano-Velasco, Estefania Dominguez, Jorge N. Franco, Diego Aranega, Amelia Eva Int J Mol Sci Review The epicardium is the outermost cell layer in the vertebrate heart that originates during development from mesothelial precursors located in the proepicardium and septum transversum. The epicardial layer plays a key role during cardiogenesis since a subset of epicardial-derived cells (EPDCs) undergo an epithelial–mesenchymal transition (EMT); migrate into the myocardium; and differentiate into distinct cell types, such as coronary vascular smooth muscle cells, cardiac fibroblasts, endothelial cells, and presumably a subpopulation of cardiomyocytes, thus contributing to complete heart formation. Furthermore, the epicardium is a source of paracrine factors that support cardiac growth at the last stages of cardiogenesis. Although several lineage trace studies have provided some evidence about epicardial cell fate determination, the molecular mechanisms underlying epicardial cell heterogeneity remain not fully understood. Interestingly, seminal works during the last decade have pointed out that the adult epicardium is reactivated after heart damage, re-expressing some embryonic genes and contributing to cardiac remodeling. Therefore, the epicardium has been proposed as a potential target in the treatment of cardiovascular disease. In this review, we summarize the previous knowledge regarding the regulation of epicardial cell contribution during development and the control of epicardial reactivation in cardiac repair after damage. MDPI 2022-03-16 /pmc/articles/PMC8950551/ /pubmed/35328640 http://dx.doi.org/10.3390/ijms23063220 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sanchez-Fernandez, Cristina
Rodriguez-Outeiriño, Lara
Matias-Valiente, Lidia
Ramirez de Acuña, Felicitas
Hernandez-Torres, Francisco
Lozano-Velasco, Estefania
Dominguez, Jorge N.
Franco, Diego
Aranega, Amelia Eva
Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview
title Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview
title_full Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview
title_fullStr Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview
title_full_unstemmed Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview
title_short Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview
title_sort regulation of epicardial cell fate during cardiac development and disease: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950551/
https://www.ncbi.nlm.nih.gov/pubmed/35328640
http://dx.doi.org/10.3390/ijms23063220
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