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Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review
Pseudomonas aeruginosa is associated with several human infections, mainly related to healthcare services. In the hospital, it is associated with resistance to several antibiotics, which poses a great challenge to therapy. However, one of the biggest challenges in treating P. aeruginosa infections i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950561/ https://www.ncbi.nlm.nih.gov/pubmed/35335624 http://dx.doi.org/10.3390/pathogens11030300 |
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author | Tuon, Felipe Francisco Dantas, Leticia Ramos Suss, Paula Hansen Tasca Ribeiro, Victoria Stadler |
author_facet | Tuon, Felipe Francisco Dantas, Leticia Ramos Suss, Paula Hansen Tasca Ribeiro, Victoria Stadler |
author_sort | Tuon, Felipe Francisco |
collection | PubMed |
description | Pseudomonas aeruginosa is associated with several human infections, mainly related to healthcare services. In the hospital, it is associated with resistance to several antibiotics, which poses a great challenge to therapy. However, one of the biggest challenges in treating P. aeruginosa infections is that related to biofilms. The complex structure of the P. aeruginosa biofilm contributes an additional factor to the pathogenicity of this microorganism, leading to therapeutic failure, in addition to escape from the immune system, and generating chronic infections that are difficult to eradicate. In this review, we address several molecular aspects of the pathogenicity of P. aeruginosa biofilms. |
format | Online Article Text |
id | pubmed-8950561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89505612022-03-26 Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review Tuon, Felipe Francisco Dantas, Leticia Ramos Suss, Paula Hansen Tasca Ribeiro, Victoria Stadler Pathogens Review Pseudomonas aeruginosa is associated with several human infections, mainly related to healthcare services. In the hospital, it is associated with resistance to several antibiotics, which poses a great challenge to therapy. However, one of the biggest challenges in treating P. aeruginosa infections is that related to biofilms. The complex structure of the P. aeruginosa biofilm contributes an additional factor to the pathogenicity of this microorganism, leading to therapeutic failure, in addition to escape from the immune system, and generating chronic infections that are difficult to eradicate. In this review, we address several molecular aspects of the pathogenicity of P. aeruginosa biofilms. MDPI 2022-02-27 /pmc/articles/PMC8950561/ /pubmed/35335624 http://dx.doi.org/10.3390/pathogens11030300 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tuon, Felipe Francisco Dantas, Leticia Ramos Suss, Paula Hansen Tasca Ribeiro, Victoria Stadler Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review |
title | Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review |
title_full | Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review |
title_fullStr | Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review |
title_full_unstemmed | Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review |
title_short | Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review |
title_sort | pathogenesis of the pseudomonas aeruginosa biofilm: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950561/ https://www.ncbi.nlm.nih.gov/pubmed/35335624 http://dx.doi.org/10.3390/pathogens11030300 |
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