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E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the distribution and deposition of inhaled [(11)C]nicotine using...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950566/ https://www.ncbi.nlm.nih.gov/pubmed/35337164 http://dx.doi.org/10.3390/ph15030367 |
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author | Wall, Anders Roslin, Sara Borg, Beatrice McDermott, Simon Walele, Tanvir Nahde, Thomas O’Connell, Grant Thompson, Joseph Lubberink, Mark Antoni, Gunnar |
author_facet | Wall, Anders Roslin, Sara Borg, Beatrice McDermott, Simon Walele, Tanvir Nahde, Thomas O’Connell, Grant Thompson, Joseph Lubberink, Mark Antoni, Gunnar |
author_sort | Wall, Anders |
collection | PubMed |
description | Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the distribution and deposition of inhaled [(11)C]nicotine using the myblu(TM) e-cigarette with two nicotine formulations, freebase and lactate salt. Fifteen healthy adult smokers participated in the two-part study to assess the distribution and accumulation of [(11)C]nicotine in the respiratory pathways and brain. Time-activity data for the respiratory pathways, lungs, oesophagus and brain were derived. 31–36% of both inhaled tracer formulations accumulated in the lung within 15–35 s. [(11)C]Nicotine(freebase) exhibited higher uptake and deposition in the upper respiratory pathways. For [(11)C]nicotine(lactate), brain deposition peaked at 4–5%, with an earlier peak and a steeper decline. A different kinetic profile was obtained for [(11)C]nicotine(lactate) with lower tracer uptake and accumulation in the upper respiratory pathways and an earlier peak and a steeper decline in lung and brain. Using nicotine lactate formulations in e-cigarettes may thus contribute to greater adult smoker acceptance and satisfaction compared to freebase formulations, potentially aiding a transition from combustible cigarettes and an acceleration of tobacco harm reduction initiatives. |
format | Online Article Text |
id | pubmed-8950566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89505662022-03-26 E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations Wall, Anders Roslin, Sara Borg, Beatrice McDermott, Simon Walele, Tanvir Nahde, Thomas O’Connell, Grant Thompson, Joseph Lubberink, Mark Antoni, Gunnar Pharmaceuticals (Basel) Article Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the distribution and deposition of inhaled [(11)C]nicotine using the myblu(TM) e-cigarette with two nicotine formulations, freebase and lactate salt. Fifteen healthy adult smokers participated in the two-part study to assess the distribution and accumulation of [(11)C]nicotine in the respiratory pathways and brain. Time-activity data for the respiratory pathways, lungs, oesophagus and brain were derived. 31–36% of both inhaled tracer formulations accumulated in the lung within 15–35 s. [(11)C]Nicotine(freebase) exhibited higher uptake and deposition in the upper respiratory pathways. For [(11)C]nicotine(lactate), brain deposition peaked at 4–5%, with an earlier peak and a steeper decline. A different kinetic profile was obtained for [(11)C]nicotine(lactate) with lower tracer uptake and accumulation in the upper respiratory pathways and an earlier peak and a steeper decline in lung and brain. Using nicotine lactate formulations in e-cigarettes may thus contribute to greater adult smoker acceptance and satisfaction compared to freebase formulations, potentially aiding a transition from combustible cigarettes and an acceleration of tobacco harm reduction initiatives. MDPI 2022-03-17 /pmc/articles/PMC8950566/ /pubmed/35337164 http://dx.doi.org/10.3390/ph15030367 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wall, Anders Roslin, Sara Borg, Beatrice McDermott, Simon Walele, Tanvir Nahde, Thomas O’Connell, Grant Thompson, Joseph Lubberink, Mark Antoni, Gunnar E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations |
title | E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations |
title_full | E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations |
title_fullStr | E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations |
title_full_unstemmed | E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations |
title_short | E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations |
title_sort | e-cigarette aerosol deposition and disposition of [(11)c]nicotine using positron emission tomography: a comparison of nicotine uptake in lungs and brain using two different nicotine formulations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950566/ https://www.ncbi.nlm.nih.gov/pubmed/35337164 http://dx.doi.org/10.3390/ph15030367 |
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