Cargando…

E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations

Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the distribution and deposition of inhaled [(11)C]nicotine using...

Descripción completa

Detalles Bibliográficos
Autores principales: Wall, Anders, Roslin, Sara, Borg, Beatrice, McDermott, Simon, Walele, Tanvir, Nahde, Thomas, O’Connell, Grant, Thompson, Joseph, Lubberink, Mark, Antoni, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950566/
https://www.ncbi.nlm.nih.gov/pubmed/35337164
http://dx.doi.org/10.3390/ph15030367
_version_ 1784675172580589568
author Wall, Anders
Roslin, Sara
Borg, Beatrice
McDermott, Simon
Walele, Tanvir
Nahde, Thomas
O’Connell, Grant
Thompson, Joseph
Lubberink, Mark
Antoni, Gunnar
author_facet Wall, Anders
Roslin, Sara
Borg, Beatrice
McDermott, Simon
Walele, Tanvir
Nahde, Thomas
O’Connell, Grant
Thompson, Joseph
Lubberink, Mark
Antoni, Gunnar
author_sort Wall, Anders
collection PubMed
description Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the distribution and deposition of inhaled [(11)C]nicotine using the myblu(TM) e-cigarette with two nicotine formulations, freebase and lactate salt. Fifteen healthy adult smokers participated in the two-part study to assess the distribution and accumulation of [(11)C]nicotine in the respiratory pathways and brain. Time-activity data for the respiratory pathways, lungs, oesophagus and brain were derived. 31–36% of both inhaled tracer formulations accumulated in the lung within 15–35 s. [(11)C]Nicotine(freebase) exhibited higher uptake and deposition in the upper respiratory pathways. For [(11)C]nicotine(lactate), brain deposition peaked at 4–5%, with an earlier peak and a steeper decline. A different kinetic profile was obtained for [(11)C]nicotine(lactate) with lower tracer uptake and accumulation in the upper respiratory pathways and an earlier peak and a steeper decline in lung and brain. Using nicotine lactate formulations in e-cigarettes may thus contribute to greater adult smoker acceptance and satisfaction compared to freebase formulations, potentially aiding a transition from combustible cigarettes and an acceleration of tobacco harm reduction initiatives.
format Online
Article
Text
id pubmed-8950566
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89505662022-03-26 E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations Wall, Anders Roslin, Sara Borg, Beatrice McDermott, Simon Walele, Tanvir Nahde, Thomas O’Connell, Grant Thompson, Joseph Lubberink, Mark Antoni, Gunnar Pharmaceuticals (Basel) Article Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the distribution and deposition of inhaled [(11)C]nicotine using the myblu(TM) e-cigarette with two nicotine formulations, freebase and lactate salt. Fifteen healthy adult smokers participated in the two-part study to assess the distribution and accumulation of [(11)C]nicotine in the respiratory pathways and brain. Time-activity data for the respiratory pathways, lungs, oesophagus and brain were derived. 31–36% of both inhaled tracer formulations accumulated in the lung within 15–35 s. [(11)C]Nicotine(freebase) exhibited higher uptake and deposition in the upper respiratory pathways. For [(11)C]nicotine(lactate), brain deposition peaked at 4–5%, with an earlier peak and a steeper decline. A different kinetic profile was obtained for [(11)C]nicotine(lactate) with lower tracer uptake and accumulation in the upper respiratory pathways and an earlier peak and a steeper decline in lung and brain. Using nicotine lactate formulations in e-cigarettes may thus contribute to greater adult smoker acceptance and satisfaction compared to freebase formulations, potentially aiding a transition from combustible cigarettes and an acceleration of tobacco harm reduction initiatives. MDPI 2022-03-17 /pmc/articles/PMC8950566/ /pubmed/35337164 http://dx.doi.org/10.3390/ph15030367 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wall, Anders
Roslin, Sara
Borg, Beatrice
McDermott, Simon
Walele, Tanvir
Nahde, Thomas
O’Connell, Grant
Thompson, Joseph
Lubberink, Mark
Antoni, Gunnar
E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
title E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
title_full E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
title_fullStr E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
title_full_unstemmed E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
title_short E-Cigarette Aerosol Deposition and Disposition of [(11)C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
title_sort e-cigarette aerosol deposition and disposition of [(11)c]nicotine using positron emission tomography: a comparison of nicotine uptake in lungs and brain using two different nicotine formulations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950566/
https://www.ncbi.nlm.nih.gov/pubmed/35337164
http://dx.doi.org/10.3390/ph15030367
work_keys_str_mv AT wallanders ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT roslinsara ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT borgbeatrice ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT mcdermottsimon ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT waleletanvir ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT nahdethomas ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT oconnellgrant ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT thompsonjoseph ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT lubberinkmark ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations
AT antonigunnar ecigaretteaerosoldepositionanddispositionof11cnicotineusingpositronemissiontomographyacomparisonofnicotineuptakeinlungsandbrainusingtwodifferentnicotineformulations