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Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures

Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral d...

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Autores principales: Inose, Hiroyuki, Kato, Tsuyoshi, Ichimura, Shoichi, Nakamura, Hiroaki, Hoshino, Masatoshi, Takahashi, Shinji, Togawa, Daisuke, Hirano, Toru, Tokuhashi, Yasuaki, Ohba, Tetsuro, Haro, Hirotaka, Tsuji, Takashi, Sato, Kimiaki, Sasao, Yutaka, Takahata, Masahiko, Otani, Koji, Momoshima, Suketaka, Hirai, Takashi, Yoshii, Toshitaka, Okawa, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950593/
https://www.ncbi.nlm.nih.gov/pubmed/35329892
http://dx.doi.org/10.3390/jcm11061566
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author Inose, Hiroyuki
Kato, Tsuyoshi
Ichimura, Shoichi
Nakamura, Hiroaki
Hoshino, Masatoshi
Takahashi, Shinji
Togawa, Daisuke
Hirano, Toru
Tokuhashi, Yasuaki
Ohba, Tetsuro
Haro, Hirotaka
Tsuji, Takashi
Sato, Kimiaki
Sasao, Yutaka
Takahata, Masahiko
Otani, Koji
Momoshima, Suketaka
Hirai, Takashi
Yoshii, Toshitaka
Okawa, Atsushi
author_facet Inose, Hiroyuki
Kato, Tsuyoshi
Ichimura, Shoichi
Nakamura, Hiroaki
Hoshino, Masatoshi
Takahashi, Shinji
Togawa, Daisuke
Hirano, Toru
Tokuhashi, Yasuaki
Ohba, Tetsuro
Haro, Hirotaka
Tsuji, Takashi
Sato, Kimiaki
Sasao, Yutaka
Takahata, Masahiko
Otani, Koji
Momoshima, Suketaka
Hirai, Takashi
Yoshii, Toshitaka
Okawa, Atsushi
author_sort Inose, Hiroyuki
collection PubMed
description Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable.
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spelling pubmed-89505932022-03-26 Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures Inose, Hiroyuki Kato, Tsuyoshi Ichimura, Shoichi Nakamura, Hiroaki Hoshino, Masatoshi Takahashi, Shinji Togawa, Daisuke Hirano, Toru Tokuhashi, Yasuaki Ohba, Tetsuro Haro, Hirotaka Tsuji, Takashi Sato, Kimiaki Sasao, Yutaka Takahata, Masahiko Otani, Koji Momoshima, Suketaka Hirai, Takashi Yoshii, Toshitaka Okawa, Atsushi J Clin Med Article Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable. MDPI 2022-03-12 /pmc/articles/PMC8950593/ /pubmed/35329892 http://dx.doi.org/10.3390/jcm11061566 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Inose, Hiroyuki
Kato, Tsuyoshi
Ichimura, Shoichi
Nakamura, Hiroaki
Hoshino, Masatoshi
Takahashi, Shinji
Togawa, Daisuke
Hirano, Toru
Tokuhashi, Yasuaki
Ohba, Tetsuro
Haro, Hirotaka
Tsuji, Takashi
Sato, Kimiaki
Sasao, Yutaka
Takahata, Masahiko
Otani, Koji
Momoshima, Suketaka
Hirai, Takashi
Yoshii, Toshitaka
Okawa, Atsushi
Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
title Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
title_full Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
title_fullStr Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
title_full_unstemmed Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
title_short Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
title_sort factors contributing to residual low back pain after osteoporotic vertebral fractures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950593/
https://www.ncbi.nlm.nih.gov/pubmed/35329892
http://dx.doi.org/10.3390/jcm11061566
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