Cargando…

Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle

Owing to a rapid increase in aging population in recent years, the deterioration of motor function in older adults has become an important social problem, and several studies have aimed to investigate the mechanisms underlying muscle function decline. Furthermore, structural maintenance of the muscl...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamamoto, Masahito, Sakiyama, Koji, Kitamura, Kei, Yamamoto, Yutaro, Takagi, Takahiro, Sekiya, Sayo, Watanabe, Genji, Taniguchi, Shuichiro, Ogawa, Yudai, Ishizuka, Satoshi, Sugiyama, Yuki, Takayama, Takeshi, Hayashi, Katsuhiko, Chang, Wei-Jen, Abe, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950615/
https://www.ncbi.nlm.nih.gov/pubmed/35328426
http://dx.doi.org/10.3390/ijms23063006
_version_ 1784675184717856768
author Yamamoto, Masahito
Sakiyama, Koji
Kitamura, Kei
Yamamoto, Yutaro
Takagi, Takahiro
Sekiya, Sayo
Watanabe, Genji
Taniguchi, Shuichiro
Ogawa, Yudai
Ishizuka, Satoshi
Sugiyama, Yuki
Takayama, Takeshi
Hayashi, Katsuhiko
Chang, Wei-Jen
Abe, Shinichi
author_facet Yamamoto, Masahito
Sakiyama, Koji
Kitamura, Kei
Yamamoto, Yutaro
Takagi, Takahiro
Sekiya, Sayo
Watanabe, Genji
Taniguchi, Shuichiro
Ogawa, Yudai
Ishizuka, Satoshi
Sugiyama, Yuki
Takayama, Takeshi
Hayashi, Katsuhiko
Chang, Wei-Jen
Abe, Shinichi
author_sort Yamamoto, Masahito
collection PubMed
description Owing to a rapid increase in aging population in recent years, the deterioration of motor function in older adults has become an important social problem, and several studies have aimed to investigate the mechanisms underlying muscle function decline. Furthermore, structural maintenance of the muscle–tendon–bone complexes in the muscle attachment sites is important for motor function, particularly for joints; however, the development and regeneration of these complexes have not been studied thoroughly and require further elucidation. Recent studies have provided insights into the roles of mesenchymal progenitors in the development and regeneration of muscles and myotendinous junctions. In particular, studies on muscles and myotendinous junctions have—through the use of the recently developed scRNA-seq—reported the presence of syncytia, thereby suggesting that fibroblasts may be transformed into myoblasts in a BMP-dependent manner. In addition, the high mobility group box 1—a DNA-binding protein found in nuclei—is reportedly involved in muscle regeneration. Furthermore, studies have identified several factors required for the formation of locomotor apparatuses, e.g., tenomodulin (Tnmd) and mohawk (Mkx), which are essential for tendon maturation.
format Online
Article
Text
id pubmed-8950615
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89506152022-03-26 Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle Yamamoto, Masahito Sakiyama, Koji Kitamura, Kei Yamamoto, Yutaro Takagi, Takahiro Sekiya, Sayo Watanabe, Genji Taniguchi, Shuichiro Ogawa, Yudai Ishizuka, Satoshi Sugiyama, Yuki Takayama, Takeshi Hayashi, Katsuhiko Chang, Wei-Jen Abe, Shinichi Int J Mol Sci Review Owing to a rapid increase in aging population in recent years, the deterioration of motor function in older adults has become an important social problem, and several studies have aimed to investigate the mechanisms underlying muscle function decline. Furthermore, structural maintenance of the muscle–tendon–bone complexes in the muscle attachment sites is important for motor function, particularly for joints; however, the development and regeneration of these complexes have not been studied thoroughly and require further elucidation. Recent studies have provided insights into the roles of mesenchymal progenitors in the development and regeneration of muscles and myotendinous junctions. In particular, studies on muscles and myotendinous junctions have—through the use of the recently developed scRNA-seq—reported the presence of syncytia, thereby suggesting that fibroblasts may be transformed into myoblasts in a BMP-dependent manner. In addition, the high mobility group box 1—a DNA-binding protein found in nuclei—is reportedly involved in muscle regeneration. Furthermore, studies have identified several factors required for the formation of locomotor apparatuses, e.g., tenomodulin (Tnmd) and mohawk (Mkx), which are essential for tendon maturation. MDPI 2022-03-10 /pmc/articles/PMC8950615/ /pubmed/35328426 http://dx.doi.org/10.3390/ijms23063006 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yamamoto, Masahito
Sakiyama, Koji
Kitamura, Kei
Yamamoto, Yutaro
Takagi, Takahiro
Sekiya, Sayo
Watanabe, Genji
Taniguchi, Shuichiro
Ogawa, Yudai
Ishizuka, Satoshi
Sugiyama, Yuki
Takayama, Takeshi
Hayashi, Katsuhiko
Chang, Wei-Jen
Abe, Shinichi
Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle
title Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle
title_full Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle
title_fullStr Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle
title_full_unstemmed Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle
title_short Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle
title_sort development and regeneration of muscle, tendon, and myotendinous junctions in striated skeletal muscle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950615/
https://www.ncbi.nlm.nih.gov/pubmed/35328426
http://dx.doi.org/10.3390/ijms23063006
work_keys_str_mv AT yamamotomasahito developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT sakiyamakoji developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT kitamurakei developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT yamamotoyutaro developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT takagitakahiro developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT sekiyasayo developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT watanabegenji developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT taniguchishuichiro developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT ogawayudai developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT ishizukasatoshi developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT sugiyamayuki developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT takayamatakeshi developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT hayashikatsuhiko developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT changweijen developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle
AT abeshinichi developmentandregenerationofmuscletendonandmyotendinousjunctionsinstriatedskeletalmuscle