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Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle
Owing to a rapid increase in aging population in recent years, the deterioration of motor function in older adults has become an important social problem, and several studies have aimed to investigate the mechanisms underlying muscle function decline. Furthermore, structural maintenance of the muscl...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950615/ https://www.ncbi.nlm.nih.gov/pubmed/35328426 http://dx.doi.org/10.3390/ijms23063006 |
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author | Yamamoto, Masahito Sakiyama, Koji Kitamura, Kei Yamamoto, Yutaro Takagi, Takahiro Sekiya, Sayo Watanabe, Genji Taniguchi, Shuichiro Ogawa, Yudai Ishizuka, Satoshi Sugiyama, Yuki Takayama, Takeshi Hayashi, Katsuhiko Chang, Wei-Jen Abe, Shinichi |
author_facet | Yamamoto, Masahito Sakiyama, Koji Kitamura, Kei Yamamoto, Yutaro Takagi, Takahiro Sekiya, Sayo Watanabe, Genji Taniguchi, Shuichiro Ogawa, Yudai Ishizuka, Satoshi Sugiyama, Yuki Takayama, Takeshi Hayashi, Katsuhiko Chang, Wei-Jen Abe, Shinichi |
author_sort | Yamamoto, Masahito |
collection | PubMed |
description | Owing to a rapid increase in aging population in recent years, the deterioration of motor function in older adults has become an important social problem, and several studies have aimed to investigate the mechanisms underlying muscle function decline. Furthermore, structural maintenance of the muscle–tendon–bone complexes in the muscle attachment sites is important for motor function, particularly for joints; however, the development and regeneration of these complexes have not been studied thoroughly and require further elucidation. Recent studies have provided insights into the roles of mesenchymal progenitors in the development and regeneration of muscles and myotendinous junctions. In particular, studies on muscles and myotendinous junctions have—through the use of the recently developed scRNA-seq—reported the presence of syncytia, thereby suggesting that fibroblasts may be transformed into myoblasts in a BMP-dependent manner. In addition, the high mobility group box 1—a DNA-binding protein found in nuclei—is reportedly involved in muscle regeneration. Furthermore, studies have identified several factors required for the formation of locomotor apparatuses, e.g., tenomodulin (Tnmd) and mohawk (Mkx), which are essential for tendon maturation. |
format | Online Article Text |
id | pubmed-8950615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89506152022-03-26 Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle Yamamoto, Masahito Sakiyama, Koji Kitamura, Kei Yamamoto, Yutaro Takagi, Takahiro Sekiya, Sayo Watanabe, Genji Taniguchi, Shuichiro Ogawa, Yudai Ishizuka, Satoshi Sugiyama, Yuki Takayama, Takeshi Hayashi, Katsuhiko Chang, Wei-Jen Abe, Shinichi Int J Mol Sci Review Owing to a rapid increase in aging population in recent years, the deterioration of motor function in older adults has become an important social problem, and several studies have aimed to investigate the mechanisms underlying muscle function decline. Furthermore, structural maintenance of the muscle–tendon–bone complexes in the muscle attachment sites is important for motor function, particularly for joints; however, the development and regeneration of these complexes have not been studied thoroughly and require further elucidation. Recent studies have provided insights into the roles of mesenchymal progenitors in the development and regeneration of muscles and myotendinous junctions. In particular, studies on muscles and myotendinous junctions have—through the use of the recently developed scRNA-seq—reported the presence of syncytia, thereby suggesting that fibroblasts may be transformed into myoblasts in a BMP-dependent manner. In addition, the high mobility group box 1—a DNA-binding protein found in nuclei—is reportedly involved in muscle regeneration. Furthermore, studies have identified several factors required for the formation of locomotor apparatuses, e.g., tenomodulin (Tnmd) and mohawk (Mkx), which are essential for tendon maturation. MDPI 2022-03-10 /pmc/articles/PMC8950615/ /pubmed/35328426 http://dx.doi.org/10.3390/ijms23063006 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yamamoto, Masahito Sakiyama, Koji Kitamura, Kei Yamamoto, Yutaro Takagi, Takahiro Sekiya, Sayo Watanabe, Genji Taniguchi, Shuichiro Ogawa, Yudai Ishizuka, Satoshi Sugiyama, Yuki Takayama, Takeshi Hayashi, Katsuhiko Chang, Wei-Jen Abe, Shinichi Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle |
title | Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle |
title_full | Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle |
title_fullStr | Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle |
title_full_unstemmed | Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle |
title_short | Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle |
title_sort | development and regeneration of muscle, tendon, and myotendinous junctions in striated skeletal muscle |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950615/ https://www.ncbi.nlm.nih.gov/pubmed/35328426 http://dx.doi.org/10.3390/ijms23063006 |
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