Sodium or Not Sodium: Should Its Presence Affect the Accuracy of Pose Prediction in Docking GPCR Antagonists?

The function of the allosteric sodium ion in stabilizing the inactive form of GPCRs has been extensively described in the past decades. Its presence has been reported to be essential for the binding of antagonist molecules in the orthosteric site of these very important therapeutical targets. Among...

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Detalles Bibliográficos
Autores principales: Bassani, Davide, Pavan, Matteo, Sturlese, Mattia, Moro, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950631/
https://www.ncbi.nlm.nih.gov/pubmed/35337144
http://dx.doi.org/10.3390/ph15030346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950631/
https://www.ncbi.nlm.nih.gov/pubmed/35337144
http://dx.doi.org/10.3390/ph15030346

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