Cargando…

Complexity of NAC Action as an Antidiabetic Agent: Opposing Effects of Oxidative and Reductive Stress on Insulin Secretion and Insulin Signaling

Dysregulated redox balance is involved in the pathogenesis of type 2 diabetes. While the benefit of antioxidants in neutralizing oxidative stress is well characterized, the potential harm of antioxidant-induced reductive stress is unclear. The aim of this study was to investigate the dose-dependent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Argaev-Frenkel, Lital, Rosenzweig, Tovit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950759/ https://www.ncbi.nlm.nih.gov/pubmed/35328386 http://dx.doi.org/10.3390/ijms23062965

Ejemplares similares

Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy
por: Argaev-Frenkel, Lital, et al.
Publicado: (2023)

N-Acetyl-l-Cysteine Supplement in Early Life or Adulthood Reduces Progression of Diabetes in Nonobese Diabetic Mice
por: Argaev Frenkel, Lital, et al.
Publicado: (2018)

Maternal N-Acetyl Cysteine Intake Improved Glucose Tolerance in Obese Mice Offspring
por: Michlin, Michal, et al.
Publicado: (2020)

Activation of Insulin Signaling by Botanical Products
por: Rosenzweig, Tovit, et al.
Publicado: (2021)

Sarcopoterium spinosum extract improved insulin sensitivity in mice models of glucose intolerance and diabetes
por: Rozenberg, Konstantin, et al.
Publicado: (2018)

Activation of Insulin Signaling in Adipocytes and Myotubes by Sarcopoterium Spinosum Extract
por: Ben-Shachar, Michaella, et al.
Publicado: (2019)

Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals
por: Saad, Ahmed, et al.
Publicado: (2012)

Regulatory effects of protein S-acylation on insulin secretion and insulin action
por: Chamberlain, Luke H., et al.
Publicado: (2021)

The Antidiabetic Functions of the Pancreas and Successful Isolation of the Antidiabetic Hormone Insulin
Publicado: (1924)

Antidiabetic effects of novel ellagic acid nanoformulation: Insulin-secreting and anti-apoptosis effects
por: Harakeh, Steve, et al.
Publicado: (2020)

When MINMOD Artifactually Interprets Strong Insulin Secretion as Weak Insulin Action
por: Ha, Joon, et al.
Publicado: (2021)

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase
por: Nguyen-Tu, Marie-Sophie, et al.
Publicado: (2022)

Insulin secretory and antidiabetic actions of Heritiera fomes bark together with isolation of active phytomolecules
por: Ansari, Prawej, et al.
Publicado: (2022)

Insulin secretion: The nitric oxide controversy
por: Gheibi, Sevda, et al.
Publicado: (2020)

Comparison of non-insulin antidiabetic agents as an add-on drug to insulin therapy in type 2 diabetes: a network meta-analysis
por: Yoon, Jeong-Hwa, et al.
Publicado: (2018)

The standardized Jamu pahitan, an Indonesian antidiabetic formulation, stimulating the glucose uptake and insulin secretion in the in-vitro models
por: Hartanti, Dwi, et al.
Publicado: (2023)

Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease
por: Hermansen, Kjeld, et al.
Publicado: (2008)

In Vivo Actions of Peroxisome Proliferator–Activated Receptors: Glycemic control, insulin sensitivity, and insulin secretion
por: Eldor, Roy, et al.
Publicado: (2013)

The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
por: Fahien, Leonard A., et al.
Publicado: (2011)

How many oral antidiabetic drugs before insulin?
por: Kelwade, Jayant, et al.
Publicado: (2017)

Insulin versus an oral antidiabetic agent as add-on therapy in type 2 diabetes after failure of an oral antidiabetic regimen: a meta-analysis
por: Gamble, JM, et al.
Publicado: (2008)

Effects of Type 2 Diabetes on Insulin Secretion, Insulin Action, Glucose Effectiveness, and Postprandial Glucose Metabolism
por: Basu, Ananda, et al.
Publicado: (2009)

Communication Between Autophagy and Insulin Action: At the Crux of Insulin Action-Insulin Resistance?
por: Frendo-Cumbo, Scott, et al.
Publicado: (2021)

Effect of insulin degludec versus sitagliptin in patients with type 2 diabetes uncontrolled on oral antidiabetic agents
por: Philis-Tsimikas, A, et al.
Publicado: (2013)

Assessment of Insulin Secretion and Insulin Resistance in Human
por: Park, So Young, et al.
Publicado: (2021)

THE HYPOPHYSIS AND SECRETION OF INSULIN
por: Houssay, B. A., et al.
Publicado: (1942)

Patients with type 2 diabetes inadequately controlled on premixed insulin: effect of initiating insulin glargine plus oral antidiabetic agents on glycaemic control in daily practice*
por: Hammer, H, et al.
Publicado: (2007)

The Therapeutic Effects of Magnesium in Insulin Secretion and Insulin Resistance
por: Hosseini Dastgerdi, Azadehalsadat, et al.
Publicado: (2022)

Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
por: Halperin, Florencia, et al.
Publicado: (2012)

Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release
por: Fetterly, Tracy L., et al.
Publicado: (2021)

Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene
por: Bartl, Jasmin, et al.
Publicado: (2011)

Insulin receptor trafficking steers insulin action
por: Hausmann, Simone, et al.
Publicado: (2016)

Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study
por: Kim, Sun H., et al.
Publicado: (2014)

Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
por: Kang, Li, et al.
Publicado: (2014)

Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.
por: Hribal, Marta L, et al.
Publicado: (2008)

Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance
por: González-Domínguez, Álvaro, et al.
Publicado: (2023)

Induction of insulin secretion in engineered liver cells by nitric oxide
por: Muniappan, Latha, et al.
Publicado: (2007)

BAG3 regulates formation of the SNARE complex and insulin secretion
por: Iorio, V, et al.
Publicado: (2015)

Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
por: Yuan, Tao, et al.
Publicado: (2021)

Clinical outcomes of basal insulin and oral antidiabetic agents as an add-on to dual therapy in patients with type 2 diabetes mellitus
por: Cheng, Chih-Ning, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0pobjg42pq01osqe1rjt45iku0