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Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Rocaglates are potent broad-spectrum antiviral compounds with a promising safety profile. They inhibit viral protein synthesis for different RNA viruses by clamping the 5′-UTRs of mRNAs onto the surface of the RNA helicase eIF4A. Apart from the natural rocaglate silvestrol, synthetic rocaglates like...

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Detalles Bibliográficos
Autores principales:	Obermann, Wiebke, Friedrich, Alexandra, Madhugiri, Ramakanth, Klemm, Paul, Mengel, Jan Philipp, Hain, Torsten, Pleschka, Stephan, Wendel, Hans-Guido, Hartmann, Roland K., Schiffmann, Susanne, Ziebuhr, John, Müller, Christin, Grünweller, Arnold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950828/ https://www.ncbi.nlm.nih.gov/pubmed/35336926 http://dx.doi.org/10.3390/v14030519

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